Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation
Asha R. Kallianpur,Lynn Hall,Meeta Yadav,Daniel W. Byrne,Ted Speroff,Ted Speroff,Robert S. Dittus,Robert S. Dittus,Jonathan L. Haines,Brian W. Christman,Marshall L. Summar +10 more
TL;DR: It is concluded that HFE C282Y is a risk factor for HVOD and that CPS polymorphisms may counteract its adverse effects, and knowledge of these genotypes and monitoring of iron stores may facilitate risk-stratification and testing of strategies to prevent HVod, such as iron chelation and pharmacologic support of the urea cycle.
Journal ArticleDOI
Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study).
Tanja B. Grammer,Marcus E. Kleber,Günther Silbernagel,Stefan Pilz,Hubert Scharnagl,Andreas Tomaschitz,Wolfgang König,Winfried März,Winfried März,Winfried März +9 more
TL;DR: Both low hemoglobin and iron depletion are independently associated with angiographic CAD, and the sTfR was only marginally associated withAngiography CAD.
Journal ArticleDOI
The relationship between the iron isotopic composition of human whole blood and iron status parameters
TL;DR: The results suggest that the conclusions made for healthy individuals are extendable to patients with aberrant iron metabolism, and the iron isotopic composition in blood from patients treated for hemochromatosis type I and from patients with anemia of chronic disease (ACD) was determined.
Book ChapterDOI
The role of iron in alcohol-mediated hepatocarcinogenesis.
Sebastian Mueller,Vanessa Rausch +1 more
TL;DR: This review summarizes the present knowledge on iron overload in patients with ALD and suggests various molecular mechanisms that involve iron regulatory protein (IRP1), transferrin receptor 1 (TfR1), and the systemic iron master switch hepcidin but not classical mutations of the HFE gene.
Journal ArticleDOI
Reversal of age-associated memory impairment by rosuvastatin in rats
Rafael Luiz Rech,Maria Noêmia Martins de Lima,Arethuza S. Dornelles,Vanessa Athaíde Garcia,Luisa Azambuja Alcalde,Gustavo Vedana,Nadja Schröder +6 more
TL;DR: Results indicated that aged animals that received iron in the neonatal period showed more severe memory deficits than vehicle-treated ones, suggesting that iron potentiates age-associated memory impairments.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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