Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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x-Irradiation in Rat Liver: Consequent Upregulation of Hepcidin and Downregulation of Hemojuvelin and Ferroportin-1 Gene Expression
Hans Christiansen,Nadeem Sheikh,Bernhard Saile,Felix Reuter,Margret Rave-Fränk,Robert Michael Hermann,Jozsef Dudas,Andrea Hille,Clemens F. Hess,Giuliano Ramadori +9 more
TL;DR: In this article, the authors evaluated the effect of x-irradiation of rat liver and isolated rat hepatocytes on hepcidin, hemojuvelin, and ferroportin-1 expression.
Journal ArticleDOI
Porphyrin-Based Metal-Organic Framework Probe: Highly Selective and Sensitive Fluorescent Turn-On Sensor for M3+ (Al3+, Cr3+, and Fe3+) Ions.
TL;DR: In this article, a highly selective and sensitive fluorescent turn-on sensor using a porphyrinic MOF, Tb-TCPP, is presented, which displays a 10-fold fluorescence enhancement in the presence of Al3+, Cr3+, and Fe3+ ions.
Journal ArticleDOI
Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis.
Manfred Nairz,Günter Weiss +1 more
TL;DR: The discovery in recent years of a plethora of new genes whose products are implicated in iron homeostasis has led to rapid expansion of knowledge in the field of iron metabolism and its underlying complex regulation in both health and disease.
Journal ArticleDOI
Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins
TL;DR: A novel fluorescent turn-on sensor based upon measuring the fluorescence enhancement of mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots (QDs@MBA) that shows a great potential for detecting glyproteins present in the complex biological or biomedical samples.
Journal ArticleDOI
Enzyme-mimic activity of ferric nano-core residing in ferritin and its biosensing applications
TL;DR: As a natural protein-caged nanoparticle with an enzyme-mimic activity, ferritin is readily conjugated with biomolecules to construct nanobiosensors, thus holds promising potential for facile and biocompatible labeling for sensitive and robust bioassays in biomedical applications.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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