Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Tissue distribution of manganese in iron-sufficient or iron-deficient rats after stainless steel welding-fume exposure.
Jung-Duck Park,Ki Young Kim,Dong-Won Kim,Seong-Jin Choi,Byung-Sun Choi,Yong Hyun Chung,Jeong Hee Han,Jae Hyuck Sung,Il Hoon Kwon,Jehyeok Mun,Il Je Yu +10 more
TL;DR: The findings suggest that the presence of Fe in the inhaled welding fumes may not have a significant effect on the uptake of Mn into the brain after the inhalation of welding fumes.
Journal ArticleDOI
A Pooled Analysis of Serum Phosphate Measurements and Potential Hypophosphataemia Events in 45 Interventional Trials with Ferric Carboxymaltose.
Giuseppe M.C. Rosano,Ingolf Schiefke,Udo-Michael Göhring,Vincent Fabien,Stefano Bonassi,Jürgen Stein +5 more
TL;DR: This pooled analysis confirms that FCM is associated with increased rates of serum PO43− lowering, but mean serum PO 43− values were seen to recover at Week 4 and further recover at week 8, and there was no correlation between laboratory serumPO43− values and the occurrence of reported adverse events related to low PO43+ levels.
Journal ArticleDOI
Both iron excess and iron depletion impair viability of rat H9C2 cardiomyocytes and L6G8C5 myocytes
Monika Kasztura,Magdalena Dzięgała,Kamil Kobak,Jacek Bania,Grzegorz Mazur,Waldemar Banasiak,Piotr Ponikowski,Ewa A. Jankowska +7 more
TL;DR: Both rat cardiomyocytes and myocyte cells contain the set of genes involved in the intracellular iron metabolism, and both types of investigated cells respond to changing iron concentrations in the cultured environment.
Journal ArticleDOI
Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.
Xiaoping Guo,Man Chen,Hongmei Zeng,Peiyi Liu,Xinghong Zhu,Feng Zhou,Jingjing Liu,Jun Zhang,Zhuangzhuang Dong,Yuhan Tang,Chao Gao,Ping Yao +11 more
TL;DR: Alcohol-induced cardiac injury is associated with excessive NTBI uptake mediated by Ang II-LTCC activation which may be mediated by quercetin against ethanol cardiotoxicity.
Journal ArticleDOI
D-propranolol attenuates lysosomal iron accumulation and oxidative injury in endothelial cells
TL;DR: It is suggested that the lysosomotropic properties of d-propranolol retarded the EC iron accumulation and thereby conferred the protective effects against iron load-mediated cytotoxicity.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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