Journal ArticleDOI
Disorders of iron metabolism.
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Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
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Book ChapterDOI
Iron Metabolism and Its Disorders
TL;DR: This chapter explains in detail iron distribution, iron absorption, and plasma iron transport, which discusses regulation of iron metabolism, iron metabolism in cells, and tests for evaluating iron metabolism.
Journal Article
Clinical nutrition: 8. The role of nutrition in the prevention of iron deficiency anemia in infants, children and adolescents
TL;DR: A 13-month-old infant is seen routinely in the office of a family physician for immunizations and periodic health examinations and in taking a developmental history, the physician notes that the child is described as being generally irritable.
Journal ArticleDOI
Oral Ferrous Sulfate Does Not Increase Preoperative Hemoglobin in Patients Scheduled for Hip or Knee Arthroplasty
Kim Lachance,Michel Savoie,Maryse Bernard,Stéphanie Rochon,Josée Fafard,Robert Robitaille,Pascal-André Vendittoli,Sylvie Levesque,Simon de Denus +8 more
TL;DR: Oral ferrous sulfate supplementation is not an effective method to increase preoperative Hb in patients scheduled for hip or knee arthroplasty, and its use is associated with adverse effects.
Transferrin Synthesis Is Increased in Nephrotic Patients Insufficiently to Replace Urinary Losses BERTHIL H. C. M. T. PRINSEN,* †‡ MONIQUE G. M. DE SAIN-VAN DER VELDEN, ‡
George A. Kaysen,Helma W. H. C. Straver,Herman J.M. van Rijn,Frans Stellaard,Ruud Berger,Ton J. Rabelink +5 more
TL;DR: In this article, transferrin synthesis was measured in vivo in nephrotic patients compared with control subjects (n 5 7) using L-(1-13 C)-valine.
Journal ArticleDOI
Monitoring intracellular labile iron pools: A novel fluorescent iron(iii) sensor as a potential non-invasive diagnosis tool
Sarah Fakih,Maria Podinovskaia,Xiaole Kong,Ulrich E. Schaible,Helen L. Collins,Robert C. Hider +5 more
TL;DR: Flow cytometry analyses demonstrated high sensitivity of the probe towards exogenous alterations of intracellular iron concentrations as well as in response to the chelation potency of iron chelators, clinically approved for treatment of iron-overload related diseases.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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