Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Sex Differences in the Association Between Serum Ferritin and Fasting Glucose in Type 2 Diabetes Among South Asian Surinamese, African Surinamese, and Ethnic Dutch: The population-based SUNSET study
Louise H. Dekker,Mary Nicolaou,Daphne L. van der A,Wim B. Busschers,Lizzy M. Brewster,Marieke B. Snijder,Karien Stronks,Irene G. M. van Valkengoed +7 more
TL;DR: A positive association between serum ferritin and type 2 diabetes and fasting glucose in the multiethnic population, which appeared stronger among women than men, and the magnitude of sex differences in the association was more pronounced in the African Surinamese group than in the other ethnic groups.
Journal ArticleDOI
Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.
TL;DR: The potential for multifunctional hydroxypyridinone-based chelators to be used as therapeutic agents against a wide range of diseases associated either with systemic or local elevated iron levels is overviewed.
Journal ArticleDOI
High serum ferritin levels are associated with metabolic risk factors in non-obese Korean young adults: Korean National Health and Nutrition Examination Survey (KNHANES) IV.
TL;DR: Investigation of the relationship between serum ferritin levels and metabolic risk factors in nonobese Korean young adults finds no clear relationship between these levels and obesity risk factors.
Journal ArticleDOI
Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress.
Subhash K. Das,Vaibhav B. Patel,Ratnadeep Basu,Wang Wang,Jessica DesAulniers,Zamaneh Kassiri,Gavin Y. Oudit +6 more
TL;DR: Male and female mice respond differently to iron‐ overload‐mediated effects on heart structure and function, and females are markedly protected from iron‐overload cardiomyopathy.
Journal ArticleDOI
Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting
Ayako Hashimoto,Katsuma Ohkura,Masakazu Takahashi,Kumiko Kizu,Hiroshi Narita,Shuichi Enomoto,Yusaku Miyamae,Seiji Masuda,Masaya Nagao,Kazuhiro Irie,Hajime Ohigashi,Glen K. Andrews,Taiho Kambe +12 more
TL;DR: The results suggest that ZIP4 targeting may represent a new strategy to improve zinc absorption in humans and confirm that soyasaponin Bb is capable of enhancing cell surface endogenous human ZIP4 in human cells.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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