Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
Journal ArticleDOI
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.
TL;DR: Human hepcidin, a 25-amino acid peptide made by hepatocytes, may be a new mediator of innate immunity and the long-sought iron-regulatory hormone and its role in iron metabolism could lead to new therapies for hemochromatosis and anemia of inflammation.
Journal ArticleDOI
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
TL;DR: The OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain and serves as a potential alternative to viral vector for gene therapy.
Journal ArticleDOI
Hepcidin and iron homeostasis.
Tomas Ganz,Elizabeta Nemeth +1 more
TL;DR: Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias.
References
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Journal ArticleDOI
A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans.
Kunihiro Yoshida,Kenichi Furihata,Shin'ichi Takeda,Akinori Nakamura,Kanji Yamamoto,Hiroshi Morita,Shuichi Hiyamuta,Shu-ichi Ikeda,Norikazu Shimizu,Nobuo Yanagisawa +9 more
TL;DR: The mutation in the Cp gene is associated with systemic hemosiderosis in humans because of a premature termination codon at the amino acid position 991 by defective splicing.
Journal Article
Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia.
TL;DR: It is concluded that unlike serum ferritin levels, which are disproportionately elevated in relation to iron stores in patients with inflammation or liver disease, the serum transferrin receptor level is not affected by these disorders and is therefore a reliable laboratory index of iron deficiency anemia.
Journal ArticleDOI
HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis.
TL;DR: The results confirm that the C282Y substitution was the main mutation involved in hemochromatosis, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the HH chromosomes that did not carry the C283Y mutation, and showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.
Journal ArticleDOI
Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.
TL;DR: This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.
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