Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
Journal ArticleDOI
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.
TL;DR: Human hepcidin, a 25-amino acid peptide made by hepatocytes, may be a new mediator of innate immunity and the long-sought iron-regulatory hormone and its role in iron metabolism could lead to new therapies for hemochromatosis and anemia of inflammation.
Journal ArticleDOI
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
TL;DR: The OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain and serves as a potential alternative to viral vector for gene therapy.
Journal ArticleDOI
Hepcidin and iron homeostasis.
Tomas Ganz,Elizabeta Nemeth +1 more
TL;DR: Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias.
References
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Journal ArticleDOI
Juvenile Hemochromatosis Locus Maps to Chromosome 1q
Antonella Roetto,A. Totaro,Mario Cazzola,M. Cicilano,Sandra Bosio,G. D'Ascola,Massimo Carella,Leopoldo Zelante,Alison L Kelly,Timothy M. Cox,Paolo Gasparini,Clara Camaschella +11 more
TL;DR: The JH locus does not correspond to the chromosomal localization of any known gene involved in iron metabolism and provides a means to recognize patients in affected families and provide a starting point for the identification of the affected gene by positional cloning.
Journal ArticleDOI
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
Abdul Waheed,Seppo Parkkila,Juha Saarnio,Robert E. Fleming,Xiao Yan Zhou,Shunji Tomatsu,Robert S. Britton,Bruce R. Bacon,William S. Sly +8 more
TL;DR: It is proposed that the HFE protein modulates the uptake of transferrin-bound iron from plasma by crypt enterocyte and participates in the mechanism by which the crypt enterocytes sense the level of body iron stores.
Journal ArticleDOI
Reticulocyte Hemoglobin Content to Diagnose Iron Deficiency in Children
TL;DR: Reticulocyte Hb content level was the strongest predictor of iron deficiency and iron deficiency anemia in children and holds promise as an alternative to biochemical iron studies in diagnosis.
Journal ArticleDOI
Management of hemochromatosis
James C. Barton,Sharon M. McDonnell,Paul C. Adams,Pierre Brissot,Lawrie W. Powell,Corwin Q. Edwards,James D. Cook,Kris V. Kowdley +7 more
TL;DR: Although iron overload often develops in patients with hemochromatosis, the demonstration of hepatic or systemic iron overload and associated complications is not needed to confirm the diagnosis and the quantity of iron removed by therapeutic phlebotomy is a valuable retrospective indicator of the severity of iron overload.
Journal ArticleDOI
HFE Genotype in Patients with Hemochromatosis and Other Liver Diseases
TL;DR: The contribution of HFE genotyping to the diagnosis of hemochromatosis was evaluated and the prevalence of H FE mutations in a group of patients with liver disease was determined.
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