Journal ArticleDOI
Disorders of iron metabolism.
Reads0
Chats0
TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
More filters
Journal ArticleDOI
Iron at the Centre of Candida albicans Interactions
Ruan Fourie,Oluwasegun Olalekan Kuloyo,Bonang M. Mochochoko,Jacobus Albertyn,Carolina H. Pohl +4 more
TL;DR: This review highlights host iron regulation as well as regulation of iron homeostasis in C. albicans and argues for the need for further research into the role of iron in polymicrobial interactions.
Journal ArticleDOI
Efficacy of Lactoferrin Oral Administration in the Treatment of Anemia and Anemia of Inflammation in Pregnant and Non-pregnant Women: An Interventional Study.
Maria Stefania Lepanto,Luigi Rosa,Antimo Cutone,Antimo Cutone,Maria Pia Conte,Rosalba Paesano,Piera Valenti +6 more
TL;DR: In this paper, an interventional study (ClinicalTrialsgov Identifier: NCT01221844) was conducted by orally administering 100 mg of 20-30% iron-saturated lactoferrin (bLf), a glycoprotein able to chelate two ferric ions per molecule, twice a day.
Journal ArticleDOI
Anaemia in the older surgical patient: a review of prevalence, causes, implications and management
Judith Partridge,Judith Partridge,Danielle Harari,Danielle Harari,Jessica Gossage,Jugdeep K. Dhesi +5 more
TL;DR: Clear differences exist between the elective and emergency surgical populations and the translation of research findings into these individual clinical settings requires more work, which should lead to a standardized approach to the management of this frequently encountered clinical scenario.
Journal ArticleDOI
Ferroportin mutation in autosomal dominant hemochromatosis: loss of function, gain in understanding
Robert E. Fleming,William S. Sly +1 more
TL;DR: A substantial percentage of individuals with hemochromatosis, especially in non–Northern European populations, have no mutations in HFE and many such cases differ from classic HH in the relative distribution of iron between the plasma, hepatocytes, and reticuloendothelial cells.
Journal ArticleDOI
Biocompatibility of Fe–O films synthesized by plasma immersion ion implantation and deposition
TL;DR: In this paper, the phase structure of the FeO films transformed from FeO to Fe3O4 with the increase of the oxygen flux. And the results of human umbilical vein endothelial cells (HUVECs) culture showed HUVEC had good adhesion and proliferation behavior on the Fe o film.
References
More filters
Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
Related Papers (5)
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more