Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Regulation of the Iron Homeostatic Hormone Hepcidin.
Veena Sangkhae,Elizabeta Nemeth +1 more
TL;DR: Current understanding of the molecular mechanisms and signaling pathways involved in the control of hepcidin synthesis in the liver, a principal determinant of plasma hePCidin concentrations, are summarized.
Journal ArticleDOI
Two New Luminescent Cd(II)-Metal–Organic Frameworks as Bifunctional Chemosensors for Detection of Cations Fe3+, Anions CrO42–, and Cr2O72– in Aqueous Solution
TL;DR: In this article, two luminescent Cd(II)-metal-organic frameworks (MOFs) have been synthesized using Cd2+ ion and L ligand in the presence of auxiliary ligands and characterized by infrared spectroscopy, elemental analysis, powder X-ray diffraction, and thermogravimetry measurement.
Journal ArticleDOI
Use of the zebrafish system to study primitive and definitive hematopoiesis.
TL;DR: Both primitive and definitive hematopoiesis in zebra fish are reviewed, various genetic methods available in the zebrafish model for studying hematopoliesis are discussed, and some of theZebrafish blood mutants identified to date are described, many of which have known human disease counterparts.
Journal ArticleDOI
Diagnosis and management of iron deficiency anaemia: a clinical update
Sant-Rayn Pasricha,Stephen Flecknoe-Brown,Stephen Flecknoe-Brown,Katrina J. Allen,Peter R. Gibson,Peter R. Gibson,Lawrence P. McMahon,Lawrence P. McMahon,John K. Olynyk,Simon D. Roger,Helen Savoia,Ramdas Tampi,Amanda Thomson,Amanda Thomson,Erica M. Wood,Erica M. Wood,Erica M. Wood,Kathryn Robinson +17 more
TL;DR: New‐generation IV products, supported by high‐quality evidence of safety and efficacy, may facilitate rapid administration of higher doses of iron, and may make it easier to integrate IV iron replacement into routine care.
Journal ArticleDOI
Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.
TL;DR: The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-Hydroxypypyran- 4-ones linked with different coumarin substituents is described to provide a series of molecular probes for the quantification of intracellular labile iron pools.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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