Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Establishment of a simple test for iron absorption from the gastrointestinal tract
Masayoshi Kobune,Koji Miyanishi,Kohichi Takada,Yutaka Kawano,Hiroyuki Nagashima,Shohei Kikuchi,Kazuyuki Murase,Satoshi Iyama,Tsutomu Sato,Yasushi Sato,Rishu Takimoto,Junji Kato +11 more
TL;DR: SFC-based OIAT using SFC was found to represent a viable screening test for the evaluation of gastrointestinal iron absorption and useful in distinguishing iron absorption between healthy volunteers, patients with iron-deficiency anemia, and patients with anemia secondary to chronic disorders.
Journal ArticleDOI
Iron Deficiency Anaemia in Reproductive Age Women Attending Obstetrics and Gynecology Outpatient of University Health Centre in Al-Ahsa, Saudi Arabia
Asia Taha,Saira Azhar,Talib Lone,Ghulam Murtaza,Shujaat A. Khan,Amara Mumtaz,Muhammad Hassham Hassan Bin Asad,Rozina Kousar,Sabiha Karim,Imran Tariq,Syed Saeed ul Hassan,Izhar Hussain +11 more
TL;DR: Iron deficiency anemia is quite prevalent in the university community especially among pregnant women, and therefore iron deficiency during pregnancy in well-educated set up needs more attention by the concerned authorities.
Journal ArticleDOI
Accurate estimate of pancreatic T2* values: how to deal with fat infiltration
Antonella Meloni,Daniele De Marchi,Vincenzo Positano,Maria Giovanna Neri,Maurizio Mangione,Petra Keilberg,Maddalena Lendini,Carla Cirotto,Alessia Pepe +8 more
TL;DR: In the clinical practice, an accurate pancreatic iron overload assessment should be done by applying FS and, when needed, by discarding the TEs until the fitting error goes below 5%.
Journal ArticleDOI
Antiproliferative and iron chelating efficiency of the new bis-8-hydroxyquinoline benzylamine chelator S1 in hepatocyte cultures
Gérard Lescoat,Gérard Lescoat,Stéphane Léonce,Alain Pierre,Lucie Gouffier,Lucie Gouffier,François Gaboriau,François Gaboriau +7 more
TL;DR: The results suggest that molecules such as S1 may constitute a promising starting point to improve cancer treatment and the iron chelating efficiency of S1 could explain at least partially its higher anti-proliferative effect compared to O-trensox.
Journal ArticleDOI
Iron overload and toxicity: implications for anesthesiologists.
TL;DR: Serum ferritin is the most widely used test to evaluate iron burden and to screen for iron overload and the management plan should be adjusted to account forIron overload and potential consequences of liver, heart, and other organ involvement.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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