Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Ferritin and serum transferrin receptor predict iron deficiency in anemic patients with rheumatoid arthritis.
Irene E. M. Bultink,Willem F. Lems,Rob J. Van De Stadt,Huibert J. Dinant,Anja Leyte,Diana S. Park,Margaret H. M. T. de Koning,Ben A. C. Dijkmans +7 more
Journal ArticleDOI
Manganese-doped gold core mesoporous silica particles as a nanoplatform for dual-modality imaging and chemo-chemodynamic combination osteosarcoma therapy.
Zhou Sha,Shuguang Yang,Liwen Fu,Mengru Geng,Jiani Gu,Xuying Liu,Shikai Li,Xiaojun Zhou,Chuanglong He +8 more
TL;DR: In this article, an effective and facile strategy is reported to construct a multifunctional nanoplatform by in situ doping metal manganese on gold core mesoporous silica nanoparticles (Au@MMSN).
Journal ArticleDOI
The three isoforms of hepcidin in human serum and their processing determined by liquid chromatography-tandem mass spectrometry (LC-tandem MS)
Lynda Addo,Katsuya Ikuta,Hiroki Tanaka,Yasumichi Toki,Mayumi Hatayama,Masayo Yamamoto,Satoshi Ito,Motohiro Shindo,Yusuke Sasaki,Yasushi Shimonaka,Mikihiro Fujiya,Yutaka Kohgo +11 more
TL;DR: In this paper, a quantitative method based on liquid chromatography-tandem mass spectrometry was used to quantify hepcidin isoforms in human serum to elucidate their characteristics and investigate the role of hepatocytes in isoform processing.
Journal ArticleDOI
Iron homeostasis disorder in piglet intestine.
Haoxuan Ding,Xiaonan Yu,Jie Feng +2 more
TL;DR: This review comprehensively review recent findings on the effects of iron deficiency and iron overload on intestinal health and will provide a rational design strategy to achieve a reasonable iron supplement, which will guide the use of iron in animal husbandry.
Journal ArticleDOI
Hematologic iron analyte values as an indicator of hepatic hemosiderosis in Callitrichidae.
Kristine M. Smith,Denise McAloose,Ann-Marie Torregrossa,Bonnie L. Raphael,Paul P. Calle,Robert P. Moore,Stephanie B. James +6 more
TL;DR: It is suggested that ferritin, serum iron concentration, and percent transferrin saturation are convenient, noninvasive, antemortem methods for assessing severity of hemosiderosis in callitrichids.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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