Diverse Pathways Generate MicroRNA-like RNAs and Dicer-Independent Small Interfering RNAs in Fungi
Heng-Chi Lee,Liande Li,Weifeng Gu,Zhihong Xue,Susan K. Crosthwaite,Alexander Pertsemlidis,Zachary A. Lewis,Michael Freitag,Eric U. Selker,Craig C. Mello,Yi Liu +10 more
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TLDR
Analysis of small RNAs associated with the Neurospora Argonaute protein QDE-2 reveals several pathways for small RNA production in filamentous fungi, shedding light on the diversity and evolutionary origins of eukaryotic smallRNAs.About:
This article is published in Molecular Cell.The article was published on 2010-06-25 and is currently open access. It has received 330 citations till now. The article focuses on the topics: Small nucleolar RNA & Argonaute.read more
Citations
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Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways
Arne Weiberg,Ming Wang,Feng Mao Lin,Hongwei Zhao,Zhihong Zhang,Isgouhi Kaloshian,Hsien Da Huang,Hailing Jin +7 more
TL;DR: This fungal pathogen transfers “virulent” sRNA effectors into host plant cells to suppress host immunity and achieve infection, which demonstrates a naturally occurring cross-kingdom RNAi as an advanced virulence mechanism.
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RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
TL;DR: A growing number of functions are emerging for RNA interference in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm, and increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery.
Journal ArticleDOI
Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis
Stephen B. Goodwin,Sarrah Ben M’Barek,Braham Dhillon,Alexander H. J. Wittenberg,Charles F. Crane,James K. Hane,Andrew J Foster,Theo van der Lee,Jane Grimwood,Andrea Aerts,John F. Antoniw,Andy M. Bailey,Burt H. Bluhm,Judith Bowler,James Bristow,Ate van der Burgt,Blondy Canto-Canché,Alice C. L. Churchill,Laura Conde-Ferráez,Hans J. Cools,Pedro M. Coutinho,Michael Csukai,Paramvir S. Dehal,Pierre J. G. M. de Wit,Bruno G. G. Donzelli,Henri van de Geest,Roeland C. H. J. van Ham,Kim E. Hammond-Kosack,Bernard Henrissat,Andrzej Kilian,Adilson Kenji Kobayashi,Edda Koopmann,Yiannis A. I. Kourmpetis,Arnold Kuzniar,Erika Lindquist,Vincent Lombard,Chris Maliepaard,Natália F. Martins,Rahim Mehrabi,Jan P. H. Nap,Alisa Ponomarenko,Jason J. Rudd,Asaf Salamov,Jeremy Schmutz,Henk J. Schouten,Harris Shapiro,Ioannis Stergiopoulos,Stefano F.F. Torriani,Hank Tu,Ronald P. de Vries,Cees Waalwijk,S.B. Ware,Ad Wiebenga,L.H. Zwiers,Richard P. Oliver,Igor V. Grigoriev,Gert H. J. Kema +56 more
TL;DR: The genome of M. graminicola was sequenced completely and found that it contained very few genes for enzymes that break down plant cell walls, which was more similar to endophytes than to pathogens, which may have evolved from endophytic ancestors.
Journal ArticleDOI
Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection
Ming Wang,Arne Weiberg,Arne Weiberg,Feng Mao Lin,Bart P. H. J. Thomma,Hsien Da Huang,Hailing Jin +6 more
TL;DR: Applying sRNAs or dsRNAs that target Botrytis DCL1 and DCL2 genes on the surface of fruits, vegetables and flowers significantly inhibits grey mould disease and represents a new generation of environmentally friendly fungicides.
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Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants
Jr-Shiuan Yang,Eric C. Lai +1 more
TL;DR: A review of Drosha-independent and Dicer-independent microRNA biogenesis strategies can be found in this paper, where the existence of noncanonical pathways has consequences for interpreting mutants in the core microRNA machinery such mutants are commonly used to assess the consequences of total microRNA loss.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
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The functions of animal microRNAs
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TL;DR: It is shown that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs are highly conserved, which suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by smallRNAs are more general than previously appreciated.
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