DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Selection of neural differentiation-specific genes by comparing profiles of random differentiation.
Lee Minsu,Dae-Hyun Jun,Chang-Il Hwang,Seung Soo Park,Jason Jongho Kang,Hyun-Seok Park,Jihoon Kim,Junil Kim,Jeong-Sun Seo,Woong-Yang Park +9 more
TL;DR: The specific genes required for neural differentiation are identified by comparing gene expressions of the guided differentiation (GD) model for dopaminergic neurons from mouse ESCs with the random differentiation (RD) model of mice ESCs into embryoid bodies.
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Methylation of the rat glial fibrillary acidic protein gene shows tissue-specific domains.
TL;DR: Four domains of methylated CpG sites are proposed on the basis of tissue and cell‐type distribution: a constitutively methylated domain in the mid‐upstream promoter; a testis‐specific gradient of methylation in exon 1; a hypomethylated domain found in neuroectodermal derivatives; and subsets of sites in the promoter and inExon 1 that have the least methylated in astrocytes, and therefore may be astro Cyt
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Formation of an active form of the interleukin-2/15 receptor beta-chain by insertion of the intracisternal A particle in a radiation-induced mouse thymic lymphoma and its role in tumorigenesis.
TL;DR: It is demonstrated that the chimeric receptor gene produced by the insertion of an IAP functions as an oncogene by providing IL‐2‐independent autonomous growth potential, a constitutively active form that transmits proliferative signals by expressing downstream target genes, including c‐myc.