DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice.
TL;DR: This study investigated whether GSH deficiency induces epigenetic alterations that impair Vitamin D metabolism genes in the livers of HFD-fed mice, and found a biochemical mechanism for the VD-deficiency and potential benefits of GSH treatment in reducing 25(OH)VD3-deficient mice.
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Nitric oxide, the new architect of epigenetic landscapes
TL;DR: An overview of the interplay between NO and epigenetics is provided as well as the unprecedented importance of these pathways to explain phenotypic effects associated with biological NO synthesis.
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Could epigenetics help explain racial disparities in chronic pain
Edwin N. Aroke,Paule V. Joseph,Abhrarup Roy,Demario S Overstreet,Trygve O. Tollefsbol,David E. Vance,Burel R. Goodin +6 more
TL;DR: A narrative review of the literature on epigenetics as a mechanism by which differential environmental exposure could explain racial differences in chronic pain is provided.
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Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life
Akhilesh Kaushal,Hongmei Zhang,Wilfried Karmaus,Todd M. Everson,Carmen J. Marsit,Margaret R. Karagas,Shih-Fen Tsai,Hui-Ju Wen,Shu-Li Wang +8 more
TL;DR: In this article, the association between in utero arsenic exposure and DNA methylation (DNAm) in cord blood and its influence in later life has been evaluated and linear mixed models were applied to assess the association of DNA m with low-density lipoprotein (LDL).
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Difference in control between spring and autumn migration in birds: insight from seasonal changes in hypothalamic gene expression in captive buntings
TL;DR: Redheaded buntings are tested for the first time seasonal transition in hypothalamic gene expressions, and differences in regulatory strategies at the transcriptional level for spring and autumn migrations in songbirds are suggested.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.