DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Epigenetic Regulations of Microglia/Macrophage Polarization in Ischemic Stroke.
Meiqian Qiu,En Xu,Lixuan Zhan +2 more
TL;DR: In this article, the authors present the recent advances in the mechanisms of epigenetics involved in regulating MM polarization, including histone modification, non-coding RNA, and DNA methylation.
Journal ArticleDOI
Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer.
TL;DR: Two high-frequency methylation sites in the RNF180 promoter region are identified, M5 (−148) and M27 (−26), which could affect gene expression and predict the prognosis of GC, which could be independent factors of prognosis.
Journal ArticleDOI
hTERT Protein Expression in Cytoplasm and Nucleus and its Association With HPV Infection in Patients With Cervical Cancer.
Pablo Moreno-Acosta,Monica Molano,Nicolás Morales,Jinneth Acosta,Cristian González-Prieto,Diana Mayorga,Lina Buitrago,Oscar Gamboa,Juan Carlos Mejía,July Castro,Alfredo Romero-Rojas,Sophie Espenel,Gerald L. Murray,Gerald L. Murray,Suzanne M. Garland,Suzanne M. Garland,Alexis Vallard,Nicolas Magné +17 more
TL;DR: HTERT protein is found in both the nucleus and cytoplasm of patients with cervical cancer and the relationship between the non-methylated status of hTERT promoter and some HPV species is confirmed as well as the relationships between these species and h TERT protein expression.
Journal ArticleDOI
Analysis of the DNA methylation pattern of the promoter region of calcitonin gene-related peptide 1 gene in patients with episodic migraine: An exploratory case-control study
Elisa Rubino,Silvia Boschi,Elisa Giorgio,Elisa Pozzi,Andrea Marcinnò,Erica Gallo,Fausto Roveta,Alberto Grassini,Alfredo Brusco,Innocenzo Rainero +9 more
TL;DR: In this article , DNA methylation level at different CpG sites in CALCA promoter correlates with several clinical characteristics of migraine, such as age at onset, presence of nausea/vomiting, depression and anxiety.
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Genome-wide characterization of aberrant DNA methylation patterns and the potential clinical implications in patients with endometrial cancer.
TL;DR: The potential applications of the detection of aberrant DNA methylation as a valuable prognostic marker for UCEC are revealed and the current findings may aid the therapeutic exploitation of UCEC treatment strategies and improve the understanding regarding the regulation of methylation in UCEC.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.