DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny.
Ki Beom Jang,Jong Hyuk Kim,Jerry M Purvis,Juxing Chen,Ping Ren,Mercedes Vazquez-Anon,Sung Woo Kim +6 more
TL;DR: Maternal supplementation of MMHAC could contribute to histone acetylation and programming in the fetus, which potentially regulates intestinal health and skeletal muscle development of piglets at birth and weaning, possibly leading to enhanced growth of their piglets.
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DNA methylation and psychotherapy response in trauma-exposed men with appetitive aggression.
Khethelo Xulu,Jacqueline S. Womersley,Jacqueline S. Womersley,Jessica Sommer,Martina Hinsberger,Thomas Elbert,Roland Weierstall,Debbie Kaminer,Stefanie Malan-Müller,Soraya Seedat,Soraya Seedat,Sian M. J. Hemmings,Sian M. J. Hemmings +12 more
TL;DR: Increased methylation of genes implicated in dopaminergic neurotransmission (NR4A2) and synaptic plasticity (AUTS2) was associated with reduced PTSD symptom severity in participants receiving FORNET and a proportional relationship between AA and TFAM, a gene involved in mitochondrial biosynthesis was revealed.
Journal ArticleDOI
The technological landscape and applications of single-cell multi-omics
TL;DR: A comprehensive review of the state-of-the-art methods in the field of single-cell multi-omics can be found in this article , where the authors highlight the impact of these methods on cell lineage tracing, tissue-specific and cell-specific atlas production, tumour immunology and cancer genetics, and mapping of cellular spatial information in fundamental and translational research.
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The role of DNA methylation in the disorders of bone metabolism
TL;DR: The purpose of this review is to compile and systematize data on the role of DNA methylation in bone metabolism in normal and pathological conditions, in the formation of osteoporosis, and to assess achievements and trends in this field of research and technologies for studyingDNA methylation.
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Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs
Iulia Szabo,Laura Muntean,Tania O. Crişan,Tania O. Crişan,Voicu Rednic,Claudia Sirbe,Simona Rednic +6 more
TL;DR: In this paper, different miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs, which could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.