DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
Rafael A. Irizarry,Christine Ladd-Acosta,Bo Wen,Zhijin Wu,Carolina Montano,Patrick Onyango,Hengmi Cui,Kevin Gabo,Michael Rongione,Maree J. Webster,Hong-Fei Ji,James B. Potash,Sarven Sabunciyan,Andrew P. Feinberg +13 more
TL;DR: Methylation changes in cancer are at sites that vary normally in tissue differentiation, consistent with the epigenetic progenitor model of cancer, which proposes that epigenetic alterations affecting tissue-specific differentiation are the predominant mechanism by which epigenetic changes cause cancer.
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DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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Conserved role of intragenic DNA methylation in regulating alternative promoters
Alika K. Maunakea,Raman P. Nagarajan,Mikhail Bilenky,Tracy J. Ballinger,Cletus D'Souza,Shaun D. Fouse,Brett E. Johnson,Chibo Hong,Cydney B. Nielsen,Yongjun Zhao,Gustavo Turecki,Allen Delaney,Richard Varhol,Nina Thiessen,Ksenya Shchors,Ksenya Shchors,Vivi M. Heine,David H. Rowitch,Xiaoyun Xing,Chris Fiore,Maximiliaan Schillebeeckx,Steven J.M. Jones,David Haussler,Marco A. Marra,Martin Hirst,Ting Wang,Ting Wang,Joseph F. Costello +27 more
TL;DR: An in-depth investigation of the human SHANK3 locus and its mouse homologue demonstrated that this tissue-specific DNA methylation regulates intragenic promoter activity in vitro and in vivo.
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A mouse Mecp2-null mutation causes neurological symptoms that mimic rett syndrome
TL;DR: The overlapping delay before symptom onset in humans and mice raises the possibility that stability of brain function, not brain development per se, is compromised by the absence of MeCP2, and generates mice lacking Mecp2 using Cre-loxP technology.
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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Steen K.T. Ooi,Chen Qiu,Emily Bernstein,Keqin Li,Da Jia,Zhe Yang,Hediye Erdjument-Bromage,Paul Tempst,Shau-Ping Lin,C. David Allis,Xiaodong Cheng,Timothy H. Bestor +11 more
TL;DR: DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2, and substitution of key residues in the binding site eliminated the H3 tail–DN MT3L interaction.