DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.
TL;DR: It is shown that DNA methyltransferase 3-like (Dnmt3L) is expressed in testes during a brief perinatal period in the non-dividing precursors of spermatogonial stem cells at a stage where retrotransposons undergo de novo methylation.
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Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
TL;DR: Using a mouse model, robust phenotypic reversal is demonstrated, as activation of MeCP2 expression leads to striking loss of advanced neurological symptoms in both immature and mature adult animals.
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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
Gabriella Ficz,Miguel R. Branco,Stefanie Seisenberger,Fátima Santos,Felix Krueger,Timothy A. Hore,C. Joana Marques,C. Joana Marques,Simon Andrews,Wolf Reik,Wolf Reik +10 more
TL;DR: The balance between hydroxymethylation and methylation in the genome is inextricably linked with the balance between pluripotency and lineage commitment.
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Covalent Modification of DNA Regulates Memory Formation
TL;DR: The results demonstrate that DNA methylation is dynamically regulated in the adult nervous system and that this cellular mechanism is a crucial step in memory formation.
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Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
TL;DR: This book aims to provide a history of DNA methylation in the immune system and some of the mechanisms leading to disease, as well as some examples of successful and unsuccessful attempts to correct these problems.