DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
Reads0
Chats0
TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
More filters
Journal ArticleDOI
Epigenetics and allergy: from basic mechanisms to clinical applications
Daniel P. Potaczek,Hani Harb,Hani Harb,Sven Michel,Bilal Alashkar Alhamwe,Harald Renz,Harald Renz,Jörg Tost +7 more
TL;DR: The potential of epigenetic changes for various clinical applications is shown: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point and new technological advances such as epigenome editing and DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
Journal ArticleDOI
Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience
TL;DR: An overview of the functional importance of oxytocin receptor gene (OXTR) promoter methylation is provided and studies that have investigated the role of OXTR methylation in behavioral phenotypes are summarized, with a discussion on the effects of traumatic experience on the developing Oxytocin system.
Journal ArticleDOI
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex
Lanfeng Wang,Yu Zhou,Liang Xu,Rui Xiao,Xingyu Lu,Liang Chen,Jenny Chong,Hairi Li,Chuan He,Xiang-Dong Fu,Dong Wang +10 more
TL;DR: The global effect of increased 5fC/5caC levels on transcription is determined, finding that such DNA modifications indeed retarded Pol II elongation on gene bodies and suggest a novel role for Pol II as a specific and direct epigenetic sensor during transcription elongation.
Journal ArticleDOI
Transgenerational epigenetic inheritance in mammals: how good is the evidence?
TL;DR: The definition of and requirement for transgenerational epigenetic inheritance is delineated, it is differentiated from the consequences of intrauterine exposure, and the available evidence in both animal models and humans is discussed.
References
More filters
Journal ArticleDOI
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.