DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
Reads0
Chats0
TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
More filters
Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
Journal ArticleDOI
Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
Journal ArticleDOI
Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
Journal ArticleDOI
Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
Journal ArticleDOI
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
More filters
Journal ArticleDOI
Genomic mapping of 5-hydroxymethylcytosine in the human brain
TL;DR: It is shown that 5hmC is more selectively targeted to genes than is 5mC, and is particularly enriched at promoters and in intragenic regions (gene bodies) but is largely absent from non-gene regions.
Journal ArticleDOI
Recruitment of DNA methyltransferase I to DNA repair sites.
TL;DR: Time lapse microscopy andletion analysis showed that Dnmt1 recruitment was mediated by the PCNA-binding domain, pointing to a direct role of DnMT1 in the restoration of epigenetic information during DNA repair.
Journal ArticleDOI
DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project
Vardhman K. Rakyan,Thomas Hildmann,K L Novik,Jörn Lewin,Jörg Tost,Antony V. Cox,T. Dan Andrews,Kevin L. Howe,Thomas J. Otto,Alexander Olek,Judith Fischer,Ivo Gut,Kurt Berlin,Stephan Beck +13 more
TL;DR: Analysis of DNA methylation levels within the major histocompatibility complex, including regulatory exonic and intronic regions associated with 90 genes in multiple tissues and individuals, reveals a bimodal distribution of methylation profiles, tissue specificity, inter-individual variation, and correlation with independent gene expression data.
Journal ArticleDOI
Prevalence of fragile X syndrome.
TL;DR: The much-quoted prevalence figure of 1:1,000 males for fragile X syndrome is an overestimate in a mixed ethnic population, but a reexamination of the individuals from whom data were derived using molecular diagnostic techniques demonstrates a more realistic figure.
Journal ArticleDOI
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
Christopher J. Klein,Maria Victoria Botuyan,Yanhong Wu,Christopher J. Ward,Garth A. Nicholson,Simon Hammans,Kaori Hojo,Hiromitch Yamanishi,Adam R. Karpf,Douglas C. Wallace,Mariella Simon,Cecilie M. Lander,Lisa A. Boardman,Julie M. Cunningham,Glenn E. Smith,William J. Litchy,Benjamin Boes,Elizabeth J. Atkinson,Sumit Middha,P. James B. Dyck,Joseph E. Parisi,Georges Mer,David I. Smith,Peter J. Dyck +23 more
TL;DR: These mutations cause premature degradation of mutant proteins, reduced methyltransferase activity and impaired heterochromatin binding during the G2 cell cycle phase leading to global hypomethylation and site-specific hypermethylation.