DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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CpG site-specific methylation as epi-biomarkers for the prediction of health risk in PAHs-exposed populations.
Lizhu Ye,Zhini He,Daochuan Li,Liping Chen,Shen Chen,Ping Guo,Dianke Yu,Lu Ma,Yong Niu,Huawei Duan,Xiumei Xing,Yongmei Xiao,Xiao-Wen Zeng,Qing Wang,Guanghui Dong,Michael Aschner,Yuxin Zheng,Wen Kuan Chen +17 more
TL;DR: In this paper , the role of altered DNA methylation in prediction of polycyclic aromatic hydrocarbons (PAHs) exposure-induced genetic damage was addressed, including diesel engine exhausts (low level) and coke oven emissions (high level) exposed subjects.
Journal ArticleDOI
Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care
Alina-Teodora Nicu,Cosmin Medar,Mariana Carmen Chifiriuc,Gratiela Gradisteanu Pircalabioru,Liliana Burlibaşa +4 more
TL;DR: The present study provides a comprehensive review of the epigenetic mechanisms–DNA methylation, histone post-translational modifications, bivalent marks, non-coding RNA–associated with TGCT susceptibility, initiation, progression and response to chemotherapy.
Journal Article
Molecular mechanisms involved in TGF-β1-induced Muscle-derived stem cells differentiation to smooth muscle cells.
TL;DR: The molecular mechanisms involved in transforming growth factor beta 1 (TGF-β1)-induced myogenic stem cell differentiation to smooth muscle cells and Sud2, Pcdh19, and Nat14 are potential core genes involved in cell differentiation are investigated.
Posted ContentDOI
DeepMOCCA: A pan-cancer prognostic model identifies personalized prognostic markers through graph attention and multi-omics data integration
Sara Althubaiti,Maxat Kulmanov,Yang Liu,Georgios V. Gkoutos,Paul N. Schofield,Robert Hoehndorf +5 more
TL;DR: DeepMOCCA can predict cancer survival time based entirely on features of the tumor at a cellular and molecular level and raises the possibility of personalized therapy based on the gene or network dominating the prognosis for that patient.
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Changes of alternative splicing in Arabidopsis thaliana grown under different CO2 concentrations
Wei Huang,Xi Chen,Qijie Guan,Zhuoheng Zhong,Ji Ma,Bingxian Yang,Tantan Wang,Wei Zhu,Jingkui Tian +8 more
TL;DR: This the first study to explore the changes of AS in plants in response to elevated CO2, which found that AS increased with the rise in CO2 concentration and that the DAS genes were associated mainly with the stimulus response.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.