DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Journal ArticleDOI
Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
TL;DR: In this paper, a minimal methyl-CpG binding domain (MBD) was isolated from MeCP2 and shown to have negligable non-specific affinity for DNA, confirming that nonspecific and methyl CpG specific binding domains are distinct.
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The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites.
TL;DR: It is demonstrated that unmethylated sites embedded in a hemimethylated context are modified at an approximately 24-fold reduced rate, which demonstrates that the enzyme accurately copies existing patterns of methylation.
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Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
Paolo Moretti,Jonathan M. Levenson,Fortunato Battaglia,Richard Atkinson,Ryan Teague,Barbara Antalffy,Dawna L. Armstrong,Ottavio Arancio,J. David Sweatt,Huda Y. Zoghbi +9 more
TL;DR: Very early symptomatic Mecp2308/Y mice had increased basal synaptic transmission and deficits in the induction of long-term depression, suggesting that functional and ultrastructural synaptic dysfunction is an early event in the pathogenesis of RTT.
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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation
TL;DR: The data suggest that MeCP2 may become abundant only once a neuron has reached a certain degree of maturity, and that this may explain some aspects of the RTT phenotype.
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Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome
Wei Xie,Cathy L. Barr,Audrey Kim,Feng Yue,Ah Young Lee,James H. Eubanks,Emma Dempster,Emma Dempster,Bing Ren,Bing Ren +9 more
TL;DR: A base-resolution, allele-specific DNA methylation map in the mouse genome is generated, finding parent-of-origin dependent (imprinted) ASM at 1,952 CG dinucleotides and a surprising presence of non-CG methylation in the adult mouse brain, with some showing evidence of imprinting.