DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency
Christian Popp,Wendy Dean,Suhua Feng,Shawn J. Cokus,Simon Andrews,Matteo Pellegrini,Steven E. Jacobsen,Wolf Reik +7 more
TL;DR: The results reveal that erasure of DNA methylation in the germ line is a global process, hence limiting the potential for transgenerational epigenetic inheritance, and indicates that AID has a critical function in epigenetic reprogramming and potentially in restricting the inheritance of epimutations in mammals.
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How Are Alkynes Scrambled
TL;DR: In this paper, the authors highlight the report by Bino et al. who have isolated a compound that is a possible catalytic intermediate in certain alkyne metathesis reactions.
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Timing of CNS Cell Generation: A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells
Xueming Qian,Qin Shen,Susan K. Goderie,Wenlei He,Alexandra Capela,Andrew A. Davis,Sally Temple +6 more
TL;DR: It is shown that isolated stem cells from the embryonic mouse cerebral cortex exhibit a distinct order of cell-type production: neuroblasts first and glioblasts later, accompanied by changes in their capacity to make neurons versus glia and in their response to the mitogen EGF.
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Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhaolan Zhou,Zhaolan Zhou,Elizabeth J. Hong,Elizabeth J. Hong,Sonia Cohen,Sonia Cohen,Wen-Ning Zhao,Hsin-Yi Henry Ho,Hsin-Yi Henry Ho,Lauren Schmidt,Wen G. Chen,Wen G. Chen,Yingxi Lin,Yingxi Lin,Erin M. Savner,Eric C. Griffith,Eric C. Griffith,Linda Hu,Judith A. Steen,Charles J. Weitz,Michael E. Greenberg,Michael E. Greenberg +21 more
TL;DR: It is shown that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism, which controls the ability of Me CP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription.
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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
Daniel Globisch,Martin Münzel,Markus Müller,Stylianos Michalakis,Mirko Wagner,Susanne Koch,Tobias Brückl,Martin Biel,Thomas Carell +8 more
TL;DR: The data suggest that an active oxidative mC demethylation pathway is unlikely to occur and show that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS.