DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex
Betina González,Subramaniam Jayanthi,Natalia Gómez,Oscar V. Torres,Máximo Hernán Sosa,Alejandra Bernardi,Francisco J. Urbano,Edgar Garcia-Rill,Jean Lud Cadet,Veronica Bisagno +9 more
TL;DR: The specific METH‐induced epigenetic and transcriptional changes described here may be related to the long‐term cognitive decline effects of the drug and its detrimental effects on mPFC function.
Journal ArticleDOI
Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs.
TL;DR: The purpose of this review is to articulate the interplay between miRNA expression and epigenetic modifications with a particular focus on its impact on the development and progression of DN.
Journal ArticleDOI
Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture
Inmaculada Hernandez,Inmaculada Hernandez,Heena Dhiman,Gerald Klanert,Vaibhav Jadhav,Norbert Auer,Michael Hanscho,Martina Baumann,Anna Esteve-Codina,Marc Dabad,Jessica Gómez,Tyler Alioto,Angelika Merkel,Emanuele Raineri,Simon Heath,Daniel Rico,Nicole Borth +16 more
TL;DR: The coding genes with the highest degree of variation in expression during the batch culture are characterized by a larger number of possible triplex‐forming interactions with differentially expressed lncRNAs, which indicates a specific role of lncRNA‐triplexes in enabling rapid and large changes in transcription.
Journal ArticleDOI
Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity
Yanchun Pan,Takuji Daito,Yo Sasaki,Yong Hee Chung,Xiaoyun Xing,Santhi Pondugula,S. Joshua Swamidass,Ting Wang,Albert H. Kim,Hiroko Yano +9 more
TL;DR: Inhibition of DNMTs in HD model primary cortical or striatal neurons restored the expression of several key genes, including Bdnf, an important neurotrophic factor implicated in HD, and raised the possibility that epigenetic strategies targeting abnormal DNA methylation may have therapeutic utility in HD.
Journal ArticleDOI
Telomerase Regulation: A Role for Epigenetics.
TL;DR: In this paper, the role of epigenetics in the regulation of telomerase activity has been investigated in cancer cell lines and showed that DNA methylation, histone modification, and non-coding RNAs are important factors for telomere activity.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.