DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases
TL;DR: The interaction between the C5 MTase from Haemophilus haemolyticus and an oligodeoxynucleotide duplex containing 2-H pyrimidinone provides a molecular explanation for the mechanism of action of the anti-cancer drug zebularine.
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CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.
Jeong Heon Lee,David G. Skalnik +1 more
TL;DR: The presence of CFP1 in this complex implicates this protein as a critical epigenetic regulator of histone modification in addition to cytosine methylation and reveals one mechanism by which this protein intersects with the epigenetic machinery.
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Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome.
TL;DR: Together, these data provide the first evidence that the loss of Mecp2 expression is accompanied by age-dependent alterations in excitatory synaptic plasticity that are likely to contribute to the cognitive and functional deficits underlying Rett syndrome.
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Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice
Catherine B. Millar,Jacky Guy,Owen J. Sansom,Jim Selfridge,Eilidh MacDougall,Brian Hendrich,Peter D. Keightley,Stefan Mark Bishop,Alan Richard Clarke,Adrian Bird +9 more
TL;DR: The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a mismatched CpG site in vitro, suggesting that it might function in vivo to minimize the mutability of 5-methylcytosine by removing its deamination product from DNA.
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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (Nature Structural and Molecular Biology (2008) 15, (268-279))
Roberta Benetti,Susana Gonzalo,Isabel Jaco,Purificación Mũoz,Susana González,Stefan Schoeftner,Elizabeth P. Murchison,Thomas Andl,Taiping Chen,Peter Klatt,En Li,Manuel Serrano,Sarah E. Millar,Gregory J. Hannon,Maria A. Blasco +14 more
TL;DR: A pathway by which miR-290 directly regulates Rbl2-dependent Dnmt expression is identified, indirectly affecting telomere-length homeostasis.