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DNA Methylation and Its Basic Function

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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.
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This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.

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Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic Sclerosis.

TL;DR: This review briefly describes the autoimmune features of systemic sclerosis and the potential pathogenic contributors including genetic/epigenetic predisposition, and environmental factors, and discusses limited data relevant to the role of long non-coding RNAs in tissue-fibrosis in SSc.
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Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta

TL;DR: In this paper , the changes in epigenetic markers in placentas from obese pregnant women following delivery by Caesarean-section at term were investigated by using varied approaches including immunocytochemistry staining, Western blot, RT-qPCR, and ELISA.
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Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution

TL;DR: It is demonstrated that the differences in the type of air pollution between localities can affect a unique change in DNA methylation profiles across the human genome.
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Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms

TL;DR: In this paper, the authors discuss 22 integrative GEM modeling methods and discuss challenges in constructing GEMs with regulation and highlight areas that need to be addressed for the successful modeling of metabolic regulation.
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Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells

TL;DR: This study suggests that PrxII may be the first thiol peroxidase that simultaneously regulates both survival and metastasis in gastric cancer cells with high clinical relevance.
References
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Journal ArticleDOI

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.

TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences

TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.
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