DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Journal ArticleDOI
Genome-wide analysis of mammalian promoter architecture and evolution
Piero Carninci,Albin Sandelin,Boris Lenhard,Boris Lenhard,Shintaro Katayama,Kazuro Shimokawa,Jasmina Ponjavic,Colin A. Semple,Martin S. Taylor,Pär G. Engström,Martin C. Frith,Alistair R. R. Forrest,Wynand Alkema,Sin Lam Tan,Charles Plessy,Rimantas Kodzius,Timothy Ravasi,Timothy Ravasi,Takeya Kasukawa,Shiro Fukuda,Mutsumi Kanamori-Katayama,Yayoi Kitazume,Hideya Kawaji,Chikatoshi Kai,Mari M. Nakamura,Hideaki Konno,Kenji Nakano,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Peter Arner,Alessandra Chesi,Stefano Gustincich,Francesca Persichetti,Harukazu Suzuki,Sean M. Grimmond,Christine A. Wells,Valerio Orlando,Claes Wahlestedt,Claes Wahlestedt,Edison T. Liu,Matthias Harbers,Jun Kawai,Vladimir B. Bajic,Vladimir B. Bajic,David A. Hume,Yoshihide Hayashizaki,Yoshihide Hayashizaki +47 more
TL;DR: These tagging methods allow quantitative analysis of promoter usage in different tissues and show that differentially regulated alternative TSSs are a common feature in protein-coding genes and commonly generate alternative N termini.
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Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
Masahiro Kaneda,Masaki Okano,Kenichiro Hata,Takashi Sado,Takashi Sado,Takashi Sado,Naomi Tsujimoto,Naomi Tsujimoto,Naomi Tsujimoto,En Li,En Li,Hiroyuki Sasaki,Hiroyuki Sasaki +12 more
TL;DR: Results indicate that both DnMT3a and Dnmt3L are required for methylation of most imprinted loci in germ cells, but also suggest the involvement of other factors.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
TL;DR: This study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals.
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A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters.
TL;DR: A direct and comprehensive survey is adopted to identify the locations of all CpGs in the human genome and finds that promoters segregate naturally into two classes by CpG content, suggesting that CpGS in the HCG class are hypomethylated in the germ line.