DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Intracisternal A-particle element transposition into the murine beta-glucuronidase gene correlates with loss of enzyme activity: a new model for beta-glucuronidase deficiency in the C3H mouse.
TL;DR: It is shown that β-glucuronidase activity is not detectable by a standard fluorometric assay in C3H/HeOuJ (C3H) mice homozygous for a new mutation, gusmps2J, which provides an opportunity to study MPS VII on a genetic background that clearly modulates disease severity.
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Methylation of the glial fibrillary acidic protein gene shows novel biphasic changes during brain development
Bruce Teter,Irina Rozovsky,Knut Krohn,Christopher P. Anderson,Heinz H. Osterburg,Caleb E. Finch +5 more
TL;DR: The GFAP promoter may be activated in rodent development by transient demethylation of a conserved brain‐specific methylation domain during development, implying evolutionary conservation and functional significance.
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DNMT3L Is a Regulator of X Chromosome Compaction and Post-Meiotic Gene Transcription
Natasha Zamudio,Natasha Zamudio,Hamish S. Scott,Katja Margrit Wolski,Chi-Yi Lo,Charity W. Law,Charity W. Law,Dillon W. Leong,Sarah Kinkel,Sarah Kinkel,Suyinn Chong,Damien Jolley,Gordon K. Smyth,David M. de Kretser,Emma Whitelaw,Moira K O'Bryan,Moira K O'Bryan +16 more
TL;DR: Previously unrecognised roles for DNMT3L in late meiosis and in the transcriptional regulation of meiotic and post-meiotic germ cells are demonstrated and provide a potential mechanism for some cases of human Klinefelter's and Turner's syndromes.
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Differential Regulation of MeCP2 Phosphorylation in the CNS by Dopamine and Serotonin
TL;DR: Combinatorial signaling through DA and 5-HT receptors can regulate the brain region- and cell-type specific pMeCP2 in the CNS, suggesting that the combinatorial regulation of cAMP by different classes of DA and5- HT receptors may contribute to the cell- type specificity of pMe CP2 induction.
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Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene
TL;DR: It is proposed that the IAP insertion isolates the promoter of the tyrosinase gene from upstream cis-acting regulatory elements, leading to a substantially decreased level of Tyr gene expression in mutants.