DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Epigenetic Mechanisms of Learning and Memory: Implications for Aging.
TL;DR: The potential source of age-related changes in the epigenome and their implications for therapeutic intervention in age- related cognitive decline are discussed.
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Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene
Christopher Butler,Samuel A. Sprowls,Gabor Szalai,Tasneem Arsiwala,Pushkar Saralkar,Benjamin Straight,Shea Hatcher,Evan Tyree,Michael Yost,William J. Kohler,Benjamin Wolff,Emily Putnam,Paul R. Lockman,Tuoen Liu +13 more
TL;DR: AZA treatment in mice with experimental brain metastases significantly reduced tumor burden and increased survival compared to vehicle and a decreased expression of keratin 18 (an epithelial maker) in 231Br cells due to hypermethylation was observed, elucidating a potential mechanism of action of AZA in treating brain metastase from breast cancer.
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Correlation Between Smoking and Passive Smoking with Multiple Sclerosis and the Underlying Molecular Mechanisms.
TL;DR: An overview of the human leukocyte antigen (HLA) gene studies on smoking and MS risk, and recent studies on between epigenetics and smoking-induced MS are discussed.
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Ancient evolutionary origins of epigenetic regulation associated with posttraumatic stress disorder.
Levent Sipahi,Monica Uddin,Zhou Cheng Hou,Allison E. Aiello,Karestan C. Koenen,Sandro Galea,Derek E. Wildman +6 more
TL;DR: It is demonstrated that few PTSD-associated CpG sites are unique to humans, while the vast majority of sites have deep evolutionary origins and were unambiguously present in the last common ancestor of humans/orangutans and humans/chimpanzees, respectively.
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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
TL;DR: In this paper, the potential of using FA as a diagnostic biomarker of age-related cognitive impairment (ARCI) has been explored, where FA plays multifaceted roles and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.