DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Oxygen in the neonatal period: Oxidative stress, oxygen load and epigenetic changes.
Sheila Lorente-Pozo,Anna Parra-Llorca,Inmaculada Lara-Cantón,Alvaro Solaz,José Luis García-Jiménez,Federico V. Pallardó,Máximo Vento +6 more
TL;DR: It is shown that the degree of DNA hyper-or hypomethylation correlates with the oxygen load provided upon stabilization, and if these epigenetic modifications would persist, oxygen supplied in the first minutes after birth could have long term consequences.
Journal ArticleDOI
Cholangiocarcinoma: new perspectives for new horizons.
Margherita Rimini,Marco Puzzoni,Federica Pedica,Nicola Silvestris,Lorenzo Fornaro,Giuseppe Aprile,Eleonora Loi,Oronzo Brunetti,Caterina Vivaldi,Francesca Simionato,Patrizia Zavattari,Mario Scartozzi,Valentina Burgio,Ratti Francesca,Luca Aldrighetti,Stefano Cascinu,Andrea Casadei-Gardini +16 more
TL;DR: A comprehensive overview of the recent highlights on Biliary tract cancer pathology can be found in this article, with a special focus on the genetic, epigenetic and molecular alterations which may have an interesting clinical application in the next future.
Journal ArticleDOI
A comprehensive evaluation of computational tools to identify differential methylation regions using RRBS data
Yi Liu,Yi Han,Liyuan Zhou,Xiaoqing Pan,Xiwei Sun,Yong Liu,Mingyu Liang,Jiale Qin,Yan Lu,Pengyuan Liu,Pengyuan Liu +10 more
TL;DR: DMRfinder, methylSig, and methylKit were the preferred tools for RRBS data analysis, in terms of their AUC and PR curves, and this comparison highlights the different applicability of DMR detection tools.
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Genome-wide DNA methylation analysis using next-generation sequencing to reveal candidate genes responsible for boar taint in pigs.
Xiao Wang,Haja N. Kadarmideen +1 more
TL;DR: This study is the first to report the genome-wide DNA methylation profiles of BT in pigs using next-generation sequencing and summarize candidate genes associated with epigenetic markers of BT, which could contribute to the understanding of the functional biology of BT traits and selective breeding of pigs against BT based on epigenetic biomarkers.
Journal ArticleDOI
Embryonic response to high beta-hydroxybutyrate (BHB) levels in postpartum dairy cows.
C. Chaput,Marc-André Sirard +1 more
TL;DR: Exposure to an energy deficit metabolic environment (high BHB) during early development appeared to modify signaling by the mTOR and sirtuins pathways in the embryo, implying mitochondrial dysfunction and inhibition of transcription, leading to slower cell division, thus programming the embryo to be more energy efficient.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.