DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
Reads0
Chats0
TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
More filters
Journal ArticleDOI
Epigenetic regulation in Huntington's disease.
TL;DR: In this article, the authors review recent studies on epigenetic regulation in huntingtin disease with a focus on DNA and histone modifications and discuss the contribution of epigenetic modifications to HD pathogenesis as well as potential mechanisms linking mutant HTT and epigenetic alterations.
Journal ArticleDOI
Contribution of age, brain region, mood disorder pathology, and interindividual factors on the methylome of human microglia.
Lot D. de Witte,Lot D. de Witte,Zhaoyu Wang,Zhaoyu Wang,Gijsje J. L. J. Snijders,Gijsje J. L. J. Snijders,Natalia Mendelev,Natalia Mendelev,Qingkun Liu,Qingkun Liu,Marjolein A. M. Sneeboer,Marjolein A. M. Sneeboer,Marco P. Boks,Yongchao Ge,Fatemeh Haghighi,Fatemeh Haghighi +15 more
TL;DR: In this article, the authors found that interindividual factors had a much larger effect on the methylation landscape of microglia than brain region, that was also seen at the transcriptome level.
Journal ArticleDOI
High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects
You Song,Jorke H. Kamstra,Yang Cao,Jana Asselman,Marc Anglès d'Auriac,Nikolai Friberg,Nikolai Friberg,Nikolai Friberg +7 more
TL;DR: A high-throughput analytical workflow for cost-efficient concentration-response analysis of epigenetic and phenotypic effects and the development of novel Adverse Outcome Pathway (AOP) networks for DNA methyltransferase (DNMT) inhibitor-mediated transgenerational effects on aquatic organisms are established.
Journal ArticleDOI
With Gottlieb beyond Gottlieb: The Role of Epigenetics in Psychobiological Development.
TL;DR: This study conceptualizes epigenetic mechanisms as molecular underpinnings mediating interactions between neural and genetic activity levels in neuronal cells in three different functional contexts: genomic, developmental, and synaptic.
Journal ArticleDOI
Vitamin B and Vitamin C Affect DNA Methylation and Amino Acid Metabolism in Mycobacterium bovis BCG.
Ningning Song,Yongqiang Zhu,Yingying Cui,Mingyue Lv,Yiyi Tang,Ziyin Cui,Guanghui Dang,Huajun Zheng,Siguo Liu +8 more
TL;DR: This study contributes to the understanding of the effects of VB1 and VC, and suggests that these vitamins constitute potential anti-tuberculosis drugs.
References
More filters
Journal ArticleDOI
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.