DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
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Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
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Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
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Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
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Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
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Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
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Kaiso Contributes to DNA Methylation-Dependent Silencing of Tumor Suppressor Genes in Colon Cancer Cell Lines
Eloisi Caldas Lopes,Ester Valls,Ester Valls,Maria E. Figueroa,Maria E. Figueroa,Alexander Mazur,Fan Guo Meng,Gabriela Chiosis,Peter W. Laird,Nicole Schreiber-Agus,John M. Greally,Egor Prokhortchouk,Ari Melnick,Ari Melnick +13 more
TL;DR: It is shown that Kaiso represses methylated tumor suppressor genes and can bind in a methylation-dependent manner to the CDKN2A in human colon cancer cell lines and could improve the efficacy of current treatment regimens.
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Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: II. Effect of Desoxyribonuclease on the Biological Activity of the Transforming Substance
Maclyn McCarty,Oswald T. Avery +1 more
TL;DR: It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance of Pneumococcus Type III.
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Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing.
François Gaudet,François Gaudet,William M. Rideout,Alexander Meissner,Jessica Dausman,Heinrich Leonhardt,Rudolph Jaenisch +6 more
TL;DR: It is found that reduction in Dnmt1 levels directly impacted methylation at this locus, leading to stable transcriptional activation of the agouti gene in the adult, and interference with this process may stably affect gene expression patterns in theAdult and may have profound phenotypic consequences.
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Sequence-specific recognition of methylated DNA by human zinc-finger proteins
TL;DR: It is reported that the human zinc-finger proteins Kaiso, Z BTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding common to other zinc- finger proteins, which suggests that many other sequence- specific methyl binding proteins may exist.
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Complexities of Rett Syndrome and MeCP2
Rodney C. Samaco,Jeffrey L. Neul +1 more
TL;DR: Rett syndrome, originally described by the Austrian pediatrician Andreas Rett, is an X-linked neurodevelopmental disorder that primarily affects girls at a frequency of 1:10,000 live female births.