DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
Reads0
Chats0
TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
More filters
Dissection ofthemethyl-CpG binding domainfromthe chromosomal protein MeCP2
TL;DR: In vitro footprinting indicates that MBD binding can protect a 12 nucleotide region surrounding a methyl-CpG pair, with an approximate dissociation constant of 10(-9) M.
Journal ArticleDOI
Epigenetic mechanisms of drug addiction.
TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
Journal ArticleDOI
Epigenetic mechanisms of drug addiction.
Jian Feng,Eric J. Nestler +1 more
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
Journal ArticleDOI
Nuclear calcium signalling in the regulation of brain function
TL;DR: Calcium signals that are induced by synaptic activity and propagate into the nucleus are a major route for synapse-to-nucleus communication and may underlie the aetiologies of various diseases, including neurodegeneration and cognitive dysfunction.
Journal ArticleDOI
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
TL;DR: The integrative analysis clearly reveals the important and conserved role of the methylation level of the first intron and its inverse association with gene expression regardless of tissue and species.
References
More filters
Journal ArticleDOI
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain
Ying-Zi Ge,Mintie Pu,Humaira Gowher,Hai-Ping Wu,Jianping Ding,Albert Jeltsch,Albert Jeltsch,Guoliang Xu +7 more
TL;DR: The data establish the PWWP domain as a novel chromatin/chromosome-targeting module and suggest that the P WWP-mediated chromatin association is essential for the function of the de novo methyltransferases during development.
Journal ArticleDOI
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants
Jie V. Deng,Ramona M. Rodriguiz,Ashley N. Hutchinson,Il Hwan Kim,William C. Wetsel,Anne E. West +5 more
TL;DR: It is shown that acute viral manipulation of MeCP2 expression in the nucleus accumbens (NAc) bidirectionally modulates amphetamine (AMPH)-induced conditioned place preference and reveals new roles for Me CP2 both in mesolimbocortical circuit development and in the regulation of psychostimulant-induced behaviors.
Journal ArticleDOI
Np95 is a histone-binding protein endowed with ubiquitin ligase activity.
Elisabetta Citterio,Roberto Papait,Francesco Nicassio,Manuela Vecchi,Paola Gomiero,Roberto Mantovani,Pier Paolo Di Fiore,Ian Marc Bonapace +7 more
TL;DR: The demonstration that Np95 is a chromatin-associated ubiquitin ligase suggests possible molecular mechanisms for its action as a cell cycle regulator.
Journal ArticleDOI
Biphasic Kinetics of the Human DNA Repair Protein MED1 (MBD4), a Mismatch-specific DNA N-Glycosylase
Fiorella Petronzelli,Fiorella Petronzelli,Antonio Riccio,George D. Markham,Steven H. Seeholzer,Jay Stoerker,Maurizio Genuardi,Anthony T. Yeung,Yoshihiro Matsumoto,Alfonso Bellacosa,Alfonso Bellacosa +10 more
TL;DR: It is shown that MED1 functions as a mismatch-specific DNA N-glycosylase active on thymine, uracil, and 5-fluorouracil when these bases are opposite to guanine, and that the 5-methylcytosine binding domain and methylation of the mismatched CpG site are not required for efficient catalysis.
Journal ArticleDOI
Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan
TL;DR: The results implicate a role for Dnmt3a in the neuromuscular control of motor movement in Mutant mice, which were born healthy, but degenerated in adulthood and died prematurely.