DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
Reads0
Chats0
TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
Citations
More filters
Journal ArticleDOI
Whole genome methylation analyses of schizophrenia patients before and after treatment.
TL;DR: The data revealed major differences in methylation profiles between male schizophrenia patients in complete remission before and after treatment and healthy controls which supports the hypothesis that antipsychotic drugs may play a role in epigenetic modifications.
Journal ArticleDOI
The effect of copper nanoparticles and copper (II) salt on redox reactions and epigenetic changes in a rat model.
Katarzyna Ognik,Ewelina Cholewińska,Jerzy Juśkiewicz,Zenon Zduńczyk,Krzysztof Tutaj,Krzysztof Tutaj,Radosław Szlązak +6 more
TL;DR: It is concluded that addition of copper nanoparticles in the diet reduces protein oxidation and nitration as well as DNA oxidation and methylation, and lowers the level of Cu increases the oxidation of proteins and DNA methylation.
Journal ArticleDOI
Paternal heat exposure causes DNA methylation and gene expression changes of Stat3 in Wild guinea pig sons.
Alexandra Weyrich,Stephanie Benz,Stephan Karl,Marie Jeschek,Katarina Jewgenow,Joerns Fickel,Joerns Fickel +6 more
TL;DR: The results indicate the presence of a paternal transgenerational epigenetic effect and quick adaptation to climatic changes may become increasingly relevant for the survival of wildlife species as global temperatures are rising.
Journal ArticleDOI
Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients
Mariam A. Fouad,Salem E. Salem,Marwa M. Hussein,Abdel-Rahman N. Zekri,Hafez F. Hafez,Eman D. El Desouky,Samia A. Shouman +6 more
TL;DR: Global DNA methylation has a significant impact on the treatment outcome and survival of Egyptian CRC patients treated with FP- based therapy.
Journal ArticleDOI
DNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications.
Francisca Salas-Pérez,Omar Ramos-Lopez,Maria L. Mansego,Fermín I. Milagro,Fermín I. Milagro,José Luis Santos,Jose I Riezu-Boj,Jose I Riezu-Boj,J. Alfredo Martínez +8 more
TL;DR: Leukocyte DNAm levels of several CpG sites located at genes involved in longevity-regulating pathways were associated with obesity and metabolic syndrome traits, suggesting a role of DNAm in aging-related metabolic alterations.
References
More filters
Journal ArticleDOI
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.