DNA Methylation and Its Basic Function
Lisa D Moore,Thuc Le,Guoping Fan +2 more
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TLDR
The investigation into DNA methylation continues to show a rich and complex picture about epigenetic gene regulation in the central nervous system and provides possible therapeutic targets for the treatment of neuropsychiatric disorders.About:
This article is published in Neuropsychopharmacology.The article was published on 2013-01-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: RNA-Directed DNA Methylation & DNA methylation.read more
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Epigenomics and gene regulation in mammalian social systems.
Tania P Guerrero,Tania P Guerrero,Jörns Fickel,Jörns Fickel,Sarah Benhaiem,Alexandra Weyrich +5 more
TL;DR: This work focuses on describing known gene–environment interactions (GEIs) and epigenetic mechanisms in different mammalian social systems and outlines the technological advances that aid the study of epigenetic mechanism in the establishment of GEIs and vice versa.
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Attachment-related dimensions in the epigenetic era: A systematic review of the human research.
Francesco Craig,Flaviana Tenuta,Veronica Rizzato,Angela Costabile,Antonio Trabacca,Rosario Montirosso +5 more
TL;DR: In this article, a systematic review focused on the potential association and interrelationship between attachment-related dimensions and DNA methylation in human studies and found significant associations between attachment related dimensions and epigenetic status in studies which considered different populations, age ranges, attachment measures and peripheral tissues.
Journal ArticleDOI
Impacts of endocrine-disrupting chemicals on prostate function and cancer
TL;DR: In this paper , the association between prostate cancer and the endocrine-disrupting functions of four prominent EDC families: bisphenols, phthalates, phytoestrogens, and mycoestrogens.
Journal ArticleDOI
The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease
Haijing Wu,Yaxiong Deng,Di Long,Ming Yang,Qianwen Li,Yu Feng,Yongjian Chen,Hong Qiu,Xin Huang,Zhenghao He,Long-Hua Hu,Heng Yin,Guang-qi Li,Yunkai Guo,Wenhan Du,Mingjing Zhao,Liwei Lu,Qianjin Lu +17 more
TL;DR: A role of AIM2 in promoting the TFH cell response is identified and it is revealed that the IL‐21‐TET2‐AIM2‐c‐MAF signalling pathway is dysregulated in lupus pathogenesis, which provides a potential therapeutic target for SLE.
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Genome-Wide DNA Methylation Analysis of a Cohort of 41 Patients Affected by Oculo-Auriculo-Vertebral Spectrum (OAVS).
Valentina Guida,Luciano Calzari,Maria Teresa Fadda,Francesca Piceci-Sparascio,Maria Cristina Digilio,Laura Bernardini,Francesco Brancati,Teresa Mattina,Daniela Melis,Francesca Forzano,Silvana Briuglia,Tommaso Mazza,Sebastiano Bianca,Enza Maria Valente,Leila Bagherjad Salehi,Paolo Prontera,Mario Pagnoni,Romano Tenconi,Bruno Dallapiccola,Giorgio Iannetti,Luigi Corsaro,Alessandro De Luca,Davide Gentilini +22 more
TL;DR: In this article, the authors evaluated the DNA-methylation profiles of 41 OAVS unrelated affected individuals by using a genome-wide microarray-based methylation approach, which revealed a moderate epigenetic variation in a large number of genes implicated in basic chromatin dynamics such as DNA packaging and protein-DNA organization.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.
Ruthie E. Amir,Ignatia B. Van den Veyver,Mimi Wan,Charles Q. Tran,Uta Francke,Huda Y. Zoghbi +5 more
TL;DR: This study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT.
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.