Dynamics in the plasma membrane: how to combine fluidity and order
Didier Marguet,Didier Marguet,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Hai-Tao He,Hai-Tao He +7 more
TLDR
The basic concepts of Brownian diffusion and lipid domain formation in model membranes are summarized and the development of ideas and tools in this field are tracked, outlining key results obtained on the dynamic processes at work in membrane structure and assembly.Abstract:
Cell membranes are fascinating supramolecular aggregates that not only form a barrier between compartments but also harbor many chemical reactions essential to the existence and functioning of a cell. Here, it is proposed to review the molecular dynamics and mosaic organization of the plasma membrane, which are thought to have important functional implications. We will first summarize the basic concepts of Brownian diffusion and lipid domain formation in model membranes and then track the development of ideas and tools in this field, outlining key results obtained on the dynamic processes at work in membrane structure and assembly. We will focus in particular on findings made using fluorescent labeling and imaging procedures to record these dynamic processes. We will also discuss a few examples showing the impact of lateral diffusion on cell signal transduction, and outline some future methodological challenges which must be met before we can answer some of the questions arising in this field of research.read more
Citations
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Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
TL;DR: The role of Caveolae/caveolin in cardiac and pulmonary pathophysiology, pharmacologic implications of caveolar localization of signaling molecules, and the possibility that caveolae might serve as a therapeutic target are reviewed.
Journal ArticleDOI
Membranes: a meeting point for lipids, proteins and therapies
Pablo V. Escribá,José M. González-Ros,Félix M. Goñi,Paavo K.J. Kinnunen,László Vígh,Lissete Sánchez-Magraner,Asia M. Fernández,Xavier Busquets,Ibolya Horváth,Gwendolyn Barceló-Coblijn +9 more
TL;DR: The role of membrane microdomains and lipid mediators in the control of heat‐shock protein response and stress sensing and signalling and the membrane sensor theory are studied.
Journal ArticleDOI
Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Werner J.H. Koopman,Leo G.J. Nijtmans,Cindy E.J. Dieteren,Peggy Roestenberg,Federica Valsecchi,Jan A.M. Smeitink,Peter H.G.M. Willems +6 more
TL;DR: The role ofCI in mitochondrial functioning; the composition, structure, and biogenesis of CI; regulation of CI function; the role of CI in ROS generation; and adaptive responses to CI deficiency are discussed.
Journal ArticleDOI
Remorin, a Solanaceae Protein Resident in Membrane Rafts and Plasmodesmata, Impairs Potato virus X Movement
Sylvain Raffaele,Emmanuelle Bayer,David Lafarge,Stéphanie Cluzet,Sylvie German Retana,Tamy Boubekeur,Nathalie Leborgne-Castel,Jean-Pierre Carde,Jeannine Lherminier,Elodie Noirot,Béatrice Satiat-Jeunemaitre,Jeanny Laroche-Traineau,Patrick Moreau,Thomas Ott,Andrew J. Maule,Philippe Reymond,Françoise Simon-Plas,Edward E. Farmer,Jean-Jacques Bessoule,Sébastien Mongrand +19 more
TL;DR: It is shown that REM can interact physically with the movement protein TRIPLE GENE BLOCK PROTEIN1 from PVX and the potential for lipid rafts to act as functional components in plasmodesmata and the plasma membrane is discussed.
Journal ArticleDOI
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Rémi Lasserre,Xiao-Jun Guo,Fabien Conchonaud,Fabien Conchonaud,Yannick Hamon,Yannick Hamon,Omar Hawchar,Omar Hawchar,Anne-Marie Bernard,Anne-Marie Bernard,Saïdi M. Soudja,Saïdi M. Soudja,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Daniel Olive,Georges Bismuth,Georges Bismuth,Jacques A. Nunès,Bernard Payrastre,Bernard Payrastre,Didier Marguet,Didier Marguet,Hai-Tao He,Hai-Tao He +25 more
TL;DR: It is reported here that highly dynamic nanodomains exist in both the outer and inner leaflets of the plasma membrane and it is demonstrated that rafts are critically involved in the activation of a signaling axis that is essential for cell physiology.
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