Journal ArticleDOI
Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: systematic evidence review for the U.S. Preventive Services Task Force.
TLDR
The results of genetic testing could lead to prevention interventions for reducing risk or mortality in mutation carriers, and experts recommend earlier and more frequent cancer screening, chemoprevention, and prophylactic surgery.Abstract:
This review supports the U.S. Preventive Services Task Force recommendations on genetic counseling and BRCA testing for susceptibility to breast and ovarian cancer.read more
Citations
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Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.
Tom Walsh,Silvia Casadei,Kathryn Hale Coats,Elizabeth M. Swisher,Sunday M. Stray,Jake Higgins,Kevin C. Roach,Jessica B. Mandell,Ming K. Lee,Sona Ciernikova,Lenka Foretova,Pavel Soucek,Mary Claire King +12 more
TL;DR: Among patients with breast cancer and severe family histories of cancer who test negative (wild type) for BRCA1 and BRCa2, approximately 12% can be expected to carry a large genomic deletion or duplication in one of these genes, and approximately 5% could carry a mutation in CHEK2 or TP53.
Journal ArticleDOI
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
Muin J. Khoury,Marta Gwinn,Paula W. Yoon,Nicole F. Dowling,Cynthia A. Moore,Linda A. Bradley +5 more
TL;DR: A framework for the continuum of multidisciplinary translation research that builds on previous characterization efforts in genomics and other areas in health care and prevention is presented and the types of translation research can overlap and provide feedback loops to allow integration of new knowledge.
Journal ArticleDOI
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers
Catharine M. Sturgeon,Michael J. Duffy,Ulf-Håkan Stenman,Hans Lilja,Nils Brünner,Daniel W. Chan,Richard J. Babaian,Robert C. Bast,Barry L. Dowell,Francisco J. Esteva,Caj Haglund,Nadia Harbeck,Daniel F. Hayes,Mads Nikolaj Holten-Andersen,George G. Klee,Rolf Lamerz,Leendert H. J. Looijenga,Rafael Molina,Hans Jørgen Nielsen,Harry G. Rittenhouse,Axel Semjonow,Ie Ming Shih,Paul Sibley,György Sölétormos,Carsten Stephan,Lori J. Sokoll,Barry Hoffman,Eleftherios P. Diamandis +27 more
TL;DR: Recommendations to encourage optimal use of tumor markers for 5 cancer sites were critically reviewed and alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are recommended for diagnosis/case finding, staging, prognosis determination, recurrence detection, and therapy monitoring.
New malignancies among cancer survivors: SEER Cancer Registries, 1973-2000.
Journal ArticleDOI
Assessing Women at High Risk of Breast Cancer: A Review of Risk Assessment Models
TL;DR: This review aims to distill the diverse literature and provide practicing clinicians with an overview of the available risk assessment methods and allow clinicians to more accurately determine which women are most likely to develop breast cancer.
References
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Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
SEER Cancer Statistics Review, 1975-2003
Lynn A. G. Ries,D. Harkins,Martin Krapcho,Angela B. Mariotto,Barry A. Miller,Eric J. Feuer,Limin X. Clegg,M. P. Eisner,Marie-Josèphe Horner,Nadia Howlader,Matthew J. Hayat,Benjamin F. Hankey,Brenda K. Edwards +12 more
Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
TL;DR: Tamoxifen decreases the incidence of invasive and noninvasive breast cancer and its use as a breast cancer preventive agent is appropriate in many women at increased risk for the disease.
Journal Article
The task force.
TL;DR: The Joint UNECE/Eurostat/OECD Working Group on Statistics for Sustainable Development (WGSSD) was commissioned by the CES in 2005 to develop a broad conceptual framework for measuring sustainable development based on the capital approach, and to identify a small set of indicators that could serve for international comparisons.
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