Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series
Nienke M Scheltema,Angela Gentile,Florencia Lución,D. James Nokes,D. James Nokes,Patrick K. Munywoki,Patrick K. Munywoki,Shabir A. Madhi,Michelle J. Groome,Cheryl Cohen,Jocelyn Moyes,Kentigern Thorburn,Somsak Thamthitiwat,Hitoshi Oshitani,Socorro Lupisan,Aubree Gordon,José F Sánchez,Katherine L. O'Brien,Bradford D. Gessner,Agustinus Sutanto,Asuncion Mejias,Asuncion Mejias,Octavio Ramilo,Octavio Ramilo,Najwa Khuri-Bulos,Natasha B. Halasa,Fernanda de-Paris,Márcia Rosane Pires,Michael C. Spaeder,Bosco Paes,Eric A. F. Simões,Ting Fan Leung,Maria Tereza da Costa Oliveira,Carla Cecília de Freitas Lázaro Emediato,Quique Bassat,Warwick Butt,Warwick Butt,Hsin Chi,Uzma Bashir Aamir,Asad Ali,Marilla G. Lucero,Rodrigo Fasce,Olga Lopez,Barbara Rath,Fernando P. Polack,Jesse Papenburg,Srđan Roglić,Hisato Ito,Edward Goka,Diederick E. Grobbee,Harish Nair,Louis Bont +51 more
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TLDR
The results show that perinatal immunisation strategies for children aged younger than 6 months could have a substantial impact on RSV-related child mortality in low-income and middle-income countries.About:
This article is published in The Lancet Global Health.The article was published on 2017-10-01 and is currently open access. It has received 180 citations till now. The article focuses on the topics: Child mortality.read more
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Predictors for the prescription of albuterol in infants hospitalized for viral bronchiolitis
Sol Maria Piña-Hincapie,Monica P Sossa-Briceño,Carlos E. Rodriguez-Martinez,Carlos E. Rodriguez-Martinez +3 more
TL;DR: Age, implementation of a CPG on viral bronchiolitis, RSV isolation, and LOS were independent predictors of prescription of albuterol in a population of infants hospitalized for viral bronChiolitis.
Journal ArticleDOI
The effect of carvacrol on respiratory syncytial virus infection in mice model: caution in the use of herbal medicines
Marzieh Faraji-Zonouz,Farshad Khodakhah,Forough Tavakoli,Alireza Tahamtan,Masoumeh Tavakoli-Yaraki,Farhad Rezaie,Talat Mokhatri-Azad,Vahid Salimi +7 more
TL;DR: Carvacrol at the concentration of 80 (mg/kg) did not show immunomodulatory activity to alleviate the RSV infection outcome and further research is needed to uncover the effects of the carVacrol intervention on virus replication and immune responses followingRSV infection.
Journal ArticleDOI
Protective Intranasal Immunization Against Influenza Virus in Infant Mice Is Dependent on IL-6.
Elizabeth Ann Bonney,Kendall Krebs,Jihye Kim,Kirtika Prakash,Blake L. Torrance,Laura Haynes,Mercedes Rincon +6 more
TL;DR: It is suggested that IL-6 may be helpful in the generation of protective immune responses in infants after intramuscular immunization does not protect against lethal challenge and intranasal administration of heat inactivated virus is protective.
Journal ArticleDOI
A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.
Stacey Human,Anne L. Hotard,Christina A. Rostad,Sujin Lee,A. Louise McCormick,Emma K. Larkin,Teresa C. T. Peret,Jaume Jorba,Joseph Lanzone,Tebeb Gebretsadik,John V. Williams,Melissa H. Bloodworth,Matthew T. Stier,Kecia N. Carroll,R. Stokes Peebles,Larry J. Anderson,Tina V. Hartert,Martin L. Moore +17 more
TL;DR: It is demonstrated that one such genotype of RSV, 2stop+A4G, present in the RSV attachment (G) gene terminus is associated with greater infant disease severity and regulation of G and F expression has implications for virulence and potentially immune evasion.
Book ChapterDOI
Respiratory syncytial virus
Flor M. Munoz,Janet A. Englund +1 more
TL;DR: RSV vaccination during pregnancy is a feasible strategy to achieve this goal and vaccines for maternal immunization against RSV are in active development and could be implemented in the near future within existing maternal-child health platforms.
References
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Journal ArticleDOI
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Rafael Lozano,Mohsen Naghavi,Kyle J Foreman,Stephen S Lim,Kenji Shibuya,Victor Aboyans,Jerry Abraham,Tim Adair,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Suzanne Barker-Collo,David Bartels,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Kavi Bhalla,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,Fiona M. Blyth,Ian Bolliger,Soufiane Boufous,Chiara Bucello,Michael Burch,Peter Burney,Jonathan R. Carapetis,Honglei Chen,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Nabila Dahodwala,Diego De Leo,Louisa Degenhardt,Allyne Delossantos,Julie O. Denenberg,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Patricia J. Erwin,Patricia Espindola,Majid Ezzati,Valery L. Feigin,Abraham D. Flaxman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Richard C. Franklin,Marlene Fransen,Michael Freeman,Sherine E. Gabriel,Emmanuela Gakidou,Flavio Gaspari,Richard F. Gillum,Diego Gonzalez-Medina,Yara A. Halasa,Diana Haring,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Bruno Hoen,Peter J. Hotez,Damian G Hoy,Kathryn H. Jacobsen,Spencer L. James,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Ganesan Karthikeyan,Nicholas J Kassebaum,Andre Keren,Jon Paul Khoo,Lisa M. Knowlton,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Michael S Lipnick,Steven E. Lipshultz,Summer Lockett Ohno,Jacqueline Mabweijano,Jacqueline Mabweijano,Michael F. Macintyre,Leslie Mallinger,Lyn March,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,John J. McGrath,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Catherine Michaud,Matthew J. Miller,Ted R. Miller,Charles Mock,Ana Olga Mocumbi,Ali A. Mokdad,Andrew E. Moran,Kim Mulholland,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Kiumarss Nasseri,Paul Norman,Martin O'Donnell,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,David Phillips,Kelsey Pierce,C. Arden Pope,Esteban Porrini,Farshad Pourmalek,Murugesan Raju,Dharani Ranganathan,Jürgen Rehm,David B. Rein,G. Remuzzi,Frederick P. Rivara,Thomas Roberts,Felipe Rodriguez De Leòn,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Joshua A. Salomon,Uchechukwu Sampson,Ella Sanman,David C. Schwebel,Maria Segui-Gomez,Donald S. Shepard,David Singh,Jessica Singleton,Karen Sliwa,Emma Smith,Andrew C Steer,Jennifer A. Taylor,Bernadette Thomas,Imad M. Tleyjeh,Jeffrey A. Towbin,Thomas Truelsen,Eduardo A. Undurraga,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Theo Vos,Gregory R. Wagner,Mengru Wang,Wenzhi Wang,Kerrianne Watt,Martin A. Weinstock,Robert G. Weintraub,James D. Wilkinson,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Paul S. F. Yip,Azadeh Zabetian,Zhi Jie Zheng,Alan D. Lopez,Christopher J L Murray +195 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
Journal ArticleDOI
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
Ting Shi,David A. McAllister,Katherine L. O'Brien,Eric A. F. Simões,Shabir A. Madhi,Bradford D. Gessner,Fernando P. Polack,Evelyn Balsells,Sozinho Acácio,Claudia Aguayo,Issifou Alassani,Asad Ali,Martin Antonio,Shally Awasthi,Juliet O. Awori,Eduardo Azziz-Baumgartner,Eduardo Azziz-Baumgartner,Henry C. Baggett,Vicky L. Baillie,Angel Balmaseda,Alfredo Barahona,Sudha Basnet,Sudha Basnet,Quique Bassat,Quique Bassat,Wilma Basualdo,Godfrey Bigogo,Louis Bont,Robert F. Breiman,W. Abdullah Brooks,W. Abdullah Brooks,Shobha Broor,Nigel Bruce,Dana Bruden,Philippe Buchy,Stuart Campbell,Phyllis Carosone-Link,Mandeep S. Chadha,James Chipeta,Monidarin Chou,Wilfrido Clara,Cheryl Cohen,Cheryl Cohen,Elizabeth de Cuellar,Duc Anh Dang,Budragchaagiin Dash-Yandag,Maria Deloria-Knoll,Mukesh Dherani,Tekchheng Eap,Bernard E. Ebruke,Marcela Echavarria,Carla Cecília de Freitas Lázaro Emediato,Rodrigo Fasce,Daniel R. Feikin,Luzhao Feng,Angela Gentile,Aubree Gordon,Doli Goswami,Doli Goswami,Sophie Goyet,Michelle J. Groome,Natasha B. Halasa,Siddhivinayak Hirve,Nusrat Homaira,Nusrat Homaira,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Jorge Jara,Imane Jroundi,Cissy B. Kartasasmita,Najwa Khuri-Bulos,Karen L. Kotloff,Anand Krishnan,Romina Libster,Romina Libster,Olga Lopez,Marilla G. Lucero,Florencia Lución,Socorro Lupisan,Debora N. Marcone,John P. McCracken,Mario Mejia,Jennifer C. Moïsi,Joel M. Montgomery,David P. Moore,Cinta Moraleda,Jocelyn Moyes,Jocelyn Moyes,Patrick K. Munywoki,Patrick K. Munywoki,Kuswandewi Mutyara,Mark P. Nicol,D. James Nokes,D. James Nokes,Pagbajabyn Nymadawa,Maria Tereza da Costa Oliveira,Histoshi Oshitani,Nitin Pandey,Gláucia Paranhos-Baccalà,Lia Neu Phillips,Valentina Picot,Mustafizur Rahman,Mala Rakoto-Andrianarivelo,Zeba A Rasmussen,Barbara Rath,Annick Robinson,Candice Romero,Graciela Russomando,Vahid Salimi,Pongpun Sawatwong,Nienke M Scheltema,Brunhilde Schweiger,J. Anthony G. Scott,J. Anthony G. Scott,Phil Seidenberg,Kunling Shen,Rosalyn J. Singleton,Rosalyn J. Singleton,Viviana Sotomayor,Tor A. Strand,Tor A. Strand,Agustinus Sutanto,Mariam Sylla,Milagritos D. Tapia,Somsak Thamthitiwat,Elizabeth Thomas,Rafal Tokarz,Claudia Turner,Marietjie Venter,Sunthareeya Waicharoen,Jianwei Wang,Wanitda Watthanaworawit,Lay-Myint Yoshida,Hongjie Yu,Heather J. Zar,Harry Campbell,Harish Nair,Harish Nair +138 more
TL;DR: In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
Journal ArticleDOI
Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis
Harish Nair,Harish Nair,Eric A. F. Simões,Igor Rudan,Bradford D. Gessner,Eduardo Azziz-Baumgartner,Jian Shayne F Zhang,Daniel R. Feikin,Daniel R. Feikin,Grant A. Mackenzie,Jennifer C Moiïsi,Anna Roca,Henry C. Baggett,Syed M. A. Zaman,Syed M. A. Zaman,Rosalyn J. Singleton,Marilla G. Lucero,Aruna Chandran,Angela Gentile,Cheryl Cohen,Anand Krishnan,Zulfiqar A Bhutta,Adriano Arguedas,Alexey Clara,Ana Lucia Andrade,Maurice Ope,Raúl Ruvinsky,María Hortal,John P. McCracken,Shabir A. Madhi,Nigel Bruce,Shamim Qazi,Saul S. Morris,Shams El Arifeen,Martin Weber,J. Anthony G. Scott,W. Abdullah Brooks,Robert F. Breiman,Harry Campbell +38 more
TL;DR: The data suggest that although 62% of children with severe ALRI are treated in hospitals, 81% of deaths happen outside hospitals, which suggests community-based management of severe disease could be an important complementary strategy to reduce pneumonia mortality and health inequities.
Journal ArticleDOI
Bronchiolitis-Associated Mortality and Estimates of Respiratory Syncytial Virus—Associated Deaths among US Children, 1979–1997
TL;DR: It was estimated that < or =510 RSV-associated deaths occurred annually during the study period, fewer than previously estimated.
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