Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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The 2H+/2e− free radical scavenging mechanisms of uric acid: thermodynamics of NH bond cleavage
TL;DR: In this paper, double (2H+/2e−) free radical scavenging mechanisms of the most abundant endogenous plasma antioxidant uric acid were theoretically studied using DFT method M05-2X/6-311++G(d, p) coupled with SMD solvation model.
Journal ArticleDOI
African American patients with gout: efficacy and safety of febuxostat vs allopurinol
TL;DR: In African American subjects with significant comorbidities, febuxostat 80 mg is significantly more efficacious than either febUXostat 40 mg or allopurinol 200/300 mg and well tolerated in this African American population.
Journal ArticleDOI
Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR.
Megan Leask,Amy Dowdle,Hamish Salvesen,Ruth Topless,Tayaza Fadason,Wenhua Wei,William Schierding,Judith Marsman,Judith Marsman,Jisha Antony,Justin M. O'Sullivan,Tony R. Merriman,Tony R. Merriman,Julia A. Horsfield,Julia A. Horsfield +14 more
TL;DR: The results are consistent with serum urate variants mediating long-range transcriptional regulation of the lincRNAs LINC01229 and MAFTRR and urate relevant genes (e.g., SLC5A8 and EHHADH) in trans.
Journal ArticleDOI
Gout in the spine
Eduardo Massato Hasegawa,Filipe Martins de Mello,Claudia Goldenstein-Schainberg,Ricardo Fuller +3 more
TL;DR: There are, however, some reports of full recovery following the usual clinical treatment for gout, suggesting that such treatment may be the initial option for those subjects with a history of gout and radiological findings of axial involvement.
Journal ArticleDOI
Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials
Christy Amanda Billy,Ricky Tanujaya Lim,Marinella Ruospo,Suetonia C. Palmer,Giovanni F.M. Strippoli +4 more
TL;DR: There is no evidence that corticosteroids and NSAID have different efficacy in managing pain in acute gout, but cortiosteroids appear to have a more favorable safety profile for selected adverse events analyzed in existing RCTs.
References
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The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
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2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
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A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.