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Gout

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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.

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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence

TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI

Uric acid transport and disease.

TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
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A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond

TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI

Where is mTOR and what is it doing there

TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Journal ArticleDOI

Primary and secondary gout

TL;DR: There is now some indication that the clinical syndrome of gout may well comprise several distinct anomalies of purine metabolism, and at least one may properly be considered a primary problem.
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Stimulation of the respiratory burst in human neutrophils by crystal phagocytosis

TL;DR: After exposure to MSU, neutrophils from patients with chronic granulomatous disease lost viability at the normal rate; thus products of the respiratory burst are not likely to be responsible for cell death.
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Crystal‐induced endogenous pyrogen production. A further look at gouty inflammation

TL;DR: The results with urate crystals have pathogenetic implications in a number of areas of gouty inflammation: initiation of the acute attack, other aspects ofThe acute-phase response, polyarticular involvement, and the inflammatory consequences of chronic stimulation by tophaceous material.
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Hyperlipidemia in primary gout.

TL;DR: The findings support the view that a metabolic association may exist in many gouty patients between serum levels of lipids and urate which is not merely an expression of atherosclerosis.
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