Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study
TL;DR: Febuxostat was more effective than allopurinol in reducing the serum urate levels of Han Chinese patients with gout or tophaceous gout who were HLA-B*5801 negative, without causing any serious skin reactions.
Journal ArticleDOI
Mapping patients' experiences from initial symptoms to gout diagnosis: a qualitative exploration
Jennifer Liddle,Edward Roddy,Christian D Mallen,Samantha L. Hider,Suman Prinjha,Sue Ziebland,Jane C Richardson +6 more
TL;DR: In this article, the authors explore patients' experiences from initial symptoms to receiving a diagnosis of gout, and report data specifically about patients' pathways to initial consultation and subsequent experiences of diagnosis.
Journal ArticleDOI
Management of hyperuricemia in asymptomatic patients: A critical appraisal
TL;DR: RCTs with hard end-points are needed to assess the risk/benefit of lowering uric acid in subjects with AH, particularly as secondary prevention for cardiovascular risk and in patients with different degrees of renal disease.
Journal ArticleDOI
The associations of serum uric acid level and hyperuricemia with knee osteoarthritis
Xiang Ding,Chao Zeng,Jie Wei,Hui Li,Tuo Yang,Yi Zhang,Yi-lin Xiong,Shu-guang Gao,Yusheng Li,Guanghua Lei +9 more
TL;DR: The findings of this study indicated that the serum uric acid concentration and prevalence of HU are positively associated with OST of the knee in the female population.
Journal ArticleDOI
Human T Lymphotropic Virus Type 1 Increases T Lymphocyte Migration by Recruiting the Cytoskeleton Organizer CRMP2
Michel Varrin-Doyer,Adeline Nicolle,Adeline Nicolle,Romain Marignier,Romain Marignier,Sylvie Cavagna,Sylvie Cavagna,Claire Benetollo,Claire Benetollo,Eric Wattel,Pascale Giraudon,Pascale Giraudon +11 more
TL;DR: Using lymphocytes cloned from infected patients and chronically infected T cells, it is found that HTLV-1 affects CRMP2 activity, resulting in an increased migratory potential, and gene expression in CD69+ cells selected from patients suggests that HT LV has the capacity to influence theCRMP2/PI3K/Akt axis thus to positively control cytoskeleton organization and lymphocyte migration.
References
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Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
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2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Book
A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.