Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
Michael Becker,H. Ralph Schumacher,Luis R. Espinoza,Alvin F. Wells,Patricia A. MacDonald,Eric E. Lloyd,Christopher Lademacher +6 more
TL;DR: In subjects with mild/moderate renal impairment, both febuxostat doses were more efficacious than allopurinol and equally safe and at the doses tested, safety of febUXostat and allopURinol was comparable.
Journal ArticleDOI
High versus low dosing of oral colchicine for early acute gout flare: Twenty‐four–hour outcome of the first multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group, dose‐comparison colchicine study
Robert Terkeltaub,Daniel E. Furst,Katherine Bennett,Karin A. Kook,R. S. Crockett,Matthew W. Davis +5 more
TL;DR: Low-dose colchicine yielded both maximum plasma concentration and early gout flare efficacy comparable with that of high-dose Colchicines, with a safety profile indistinguishable from that of placebo.
Journal ArticleDOI
Uric acid as a danger signal in gout and its comorbidities
TL;DR: Surprisingly, the same mechanisms underlie the inflammatory response to a number of irritant particles, many of which also cause disease, as well as pointing to potential new therapeutic targets for this and other sterile inflammatory diseases.
Journal ArticleDOI
Update on gout: new therapeutic strategies and options.
TL;DR: Novel approaches will hopefully lead to improved management of hyperuricemia and gout, and also to improvements in patient-centered outcomes, even for those who have previously failed to respond to treatment.
Journal ArticleDOI
Gout: An old disease in new perspective – A review
TL;DR: Gout is a picturesque presentation of uric acid disturbance as mentioned in this paper, it is the most well understood and described type of arthritis. Diagnosis is based on laboratory and radiological features, the gold standard of diagnosis is identification of characteristic MSU crystals in the synovial fluid using polarized light microscopy.
References
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Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
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2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Book
A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.