Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
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Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300–600 mg/day versus benzbromarone 100–200 mg/day in patients with gout
M.K. Reinders,C.J. Haagsma,T.L.Th.A. Jansen,van Eric Roon,J. Delsing,M.A.F.J. van de Laar,Jacobus R. B. J. Brouwers +6 more
TL;DR: Increasing the allopurinol dose from 300 to 600 mg/day and the benzbromarone dose from 100 to 200 mg/ day according to the target sUr produced significantly higher success rates (both 78% successful in attaining sUr ⩽0.30 mmol/l).
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Hyperuricemia, gout and the metabolic syndrome.
TL;DR: Clinicians should be aware of the presence of metabolic syndrome in patients with hyperuricemia or gout in order to control its components (high blood pressure, obesity, etc.) and hence reduce the risk for cardiovascular disease.
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Concomitant septic and gouty arthritis—an analysis of 30 cases
TL;DR: Septic arthritis coexistent with gout presented a diagnostic difficulty and an early diagnosis requires a high level of suspicion, regardless of the absence of fever or leucocytosis.
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Mechanisms of bone erosion in gout; a quantitative analysis using plain radiography and computed tomography.
Nicola Dalbeth,Barnaby Clark,Kate Gregory,Greg D. Gamble,Timothy Sheehan,Anthony Doyle,Fiona M McQueen +6 more
TL;DR: The results strongly implicate tophus infiltration into bone as the dominant mechanism for the development of bone erosion and joint damage in gout.