Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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Journal ArticleDOI
Lower limb cellulitis and its mimics: Part I. Lower limb cellulitis
TL;DR: The epidemiology and treatment of lower limb cellulitis is summarized, which shows that older age, obesity, venous insufficiency, saphenous venectomy, and edema are the most important predisposing factors.
Journal ArticleDOI
Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator.
Robert Terkeltaub,H. Ralph Schumacher,John D. Carter,Herbert S B Baraf,Robert Evans,Jian Wang,Shirletta King-Davis,Steven P. Weinstein +7 more
TL;DR: Although generally well-tolerated, rilonACEpt in combination with indomethacin and rilonacept alone did not provide additional pain relief over 72 hours relative to indometHacin alone in patients with acute gout flare.
Journal ArticleDOI
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial.
Yuanlu Shi,Gary Williamson +1 more
TL;DR: Daily supplementation of 500 mg quercetin, containing the bioavailable amount of quercETin as present in approximately 100 g red onions, for 4 weeks, significantly reduces elevated plasma uric acid concentrations in healthy males.
Journal ArticleDOI
Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.
TL;DR: It is argued that hyperuricemia is a main culprit in the development of the long‐term systemic inflammation seen in gout and it is enforced that urate is a metabolite that can induce innate immune memory.
Journal ArticleDOI
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
Owen M. Woodward,Deepali N. Tukaye,Jinming Cui,Patrick Greenwell,Leeza Constantoulakis,Benjamin S. Parker,Anjana Rao,Michael Köttgen,Peter C. Maloney,William B. Guggino +9 more
TL;DR: The utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout is demonstrated.
References
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Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
Journal ArticleDOI
2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
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A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.