Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats.
TL;DR: The effects on glucose tolerance of prolonged fructose feeding, at a level approximating that currently in the American diet, were examined in weaning, male Wistar rate, and liver phosphoenolpyruvate carboxykinase activity was higher, indicating higher gluconeogenic activity.
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Febuxostat (TMX‐67), a Novel, Non‐Purine, Selective Inhibitor of Xanthine Oxidase, Is Safe and Decreases Serum Urate in Healthy Volunteers
Michael Becker,J. Kisicki,R. Khosravan,Jing-Tao Wu,D. Mulford,Barbara Hunt,Patricia A. MacDonald,Nancy Joseph-Ridge +7 more
TL;DR: Febuxostat is a safe and potent hypouricemic agent in healthy humans and inhibition of xanthine oxidase activity by febuxostats is confirmed.
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Characterising the clinical and biomechanical features of severely deformed feet in rheumatoid arthritis
Deborah E. Turner,James Woodburn +1 more
TL;DR: Abnormal gait patterns were identified and were distinguishable among those patients with predominantly forefoot, rearfoot or combined foot deformity and localised disease impact was determined.
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Gout, hyperlipidemia, and diabetes interrelationships.
TL;DR: The results indicate that abnormalities in triglyceride metabolism may be a fundamental factor in the pathogenesis of diabetes and that the presence of hypertriglyceridemia may be used to predict the existence of coexistent diabetes.
Journal Article
ACTH revisited: effective treatment for acute crystal induced synovitis in patients with multiple medical problems.
TL;DR: ACTH is a safe and effective treatment for acute gout and pseudogout, especially in patients with multiple medical problems, especially during the first few days of treatment with parenteral ACTH.