Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
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Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy.
Jeremy Turner,J. M. Stacey,B. Harding,Peter Kotanko,Karl Lhotta,Juan G. Puig,Ian Roberts,Rosa J. Torres,Rajesh V. Thakker +8 more
TL;DR: The results of studies which have identified the gene causing FJHN indicate a further, novel role for UROMODULIN in urate metabolism, which is an 85 Kda glycoprotein, which has roles in renal stone formation, the modulation of immune responses, and urothelial cytoprotection.
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Dual-energy computed tomography for the differentiation of uric acid stones: ex vivo performance evaluation
Paul Stolzmann,Hans Scheffel,Katharina Rentsch,Thomas Schertler,Thomas Frauenfelder,Sebastian Leschka,Tullio Sulser,Borut Marincek,Hatem Alkadhi +8 more
TL;DR: Ex vivo experience indicates that differentiation between UA- and non-UA-containing stones can be accurately performed using dual-source dual-energy CT.
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Clinical, physiological and biochemical studies of a patient with xanthinuria and pheochromocytoma
TL;DR: This is the second known case of xanthinuria as well as the results of extensive clinical and biochemical studies which further define the nature of this metabolic disorder.
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Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study
Qiong Yang,Chao-Yu Guo,L. Adrienne Cupples,Daniel Levy,Peter W.F. Wilson,Caroline S. Fox,Caroline S. Fox +6 more
TL;DR: Several novel loci linked to uric acid are identified and further research is necessary to identify the genes involved in uric Acid metabolism and their roles in hypertension, cardiovascular disease, and renal disease.
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Similar Functions of Uric Acid and Ascorbate in Man
TL;DR: Orowan1 first proposed that the emergence of intelligence in the primate line might arise from a single evolutionary event, the loss of the enzyme uricase, with the result that uric acid became the end product of purine metabolism.