Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
Journal ArticleDOI
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Acute uric acid nephropathy.
TL;DR: The keys to the diagnosis of acute uric acid nephropathy are the appropriate clinical setting of increased cell lysis, oliguria, marked hyperuricemia, andhyperuricosuria, and a urinary uric Acid-to-creatinine ratio greater than 1 helps to distinguish acute uriatic acid nePhropathy from other catabolic forms of acute renal failure in which serum urate is elevated.
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Some observations on 520 gouty patients.
William C. Kuzell,Ralph W. Schaffarzick,W. Edward Naugler,Peter Koets,Eldon A. Mankle,Beverly J. Brown,Barbara Champlin +6 more
TL;DR: Of the currently available antigout agents phenylbutazone is the single most effective remedy, valuable at once in termination of acute gouty arthritis, prevention of acute exacerbations, and control of chronic goutY arthritis.
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Z-nucleotide accumulation in erythrocytes from Lesch-Nyhan patients.
TL;DR: It is concluded that Z-nucleotide formation may result from markedly increased rates of de novo purine biosynthesis, and is possible that metabolites of these purine intermediates may play a role in the pathogenesis of the Lesch-Nyhan syndrome.
Journal ArticleDOI
Genotype-based changes in serum uric acid affect blood pressure.
Afshin Parsa,Eric Brown,Matthew R. Weir,Jeffrey C. Fink,Alan R. Shuldiner,Braxton D. Mitchell,Patrick F. McArdle +6 more
TL;DR: A Mendelian randomization analysis using variants in the GLUT9 gene indicates that a decrease in serum uric acid has a causal effect of lowering blood pressure.
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Chylomicronemia Syndrome in Diabetes Mellitus
TL;DR: A number of clinical and biochemical features observed in the diabetic patients and also in a group of nondiabetic controls with comparable degrees of hypertriglyceridemia suggests that these manifestations are related to high plasma triglyceride levels rather than to the diabetes per se.