Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
Journal ArticleDOI
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Journal ArticleDOI
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
Qiong Yang,Anna Köttgen,Abbas Dehghan,Albert V. Smith,Nicole L. Glazer,Ming-Huei Chen,Ming-Huei Chen,Daniel I. Chasman,Thor Aspelund,Gudny Eiriksdottir,Tamara B. Harris,Lenore J. Launer,Mike A. Nalls,Dena G. Hernandez,Dan E. Arking,Eric Boerwinkle,Megan L. Grove,Man Li,W. H. Linda Kao,Michel Chonchol,Michel Chonchol,Talin Haritunians,Talin Haritunians,Guo Li,Thomas Lumley,Bruce M. Psaty,Bruce M. Psaty,Michael G. Shlipak,Shih-Jen Hwang,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Ashish Upadhyay,Cornelia M. van Duijn,Albert Hofman,Fernando Rivadeneira,Bruno H. Stricker,André G. Uitterlinden,Guillaume Paré,Alex Parker,Paul M. Ridker,David S. Siscovick,Vilmundur Gudnason,Jacqueline C.M. Witteman,Caroline S. Fox,Caroline S. Fox,Josef Coresh +47 more
TL;DR: The genetic urate score analysis suggested a causal relationship between serum urate and gout but did not provide evidence for one between serum Urate and cardiovascular risk factors and coronary heart disease (CHD).
Journal ArticleDOI
Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.
Paul E. Marik,Joseph Varon +1 more
TL;DR: The clinical benefit of dietary fish oil supplementation in preventing cardiovascular events in both high and low risk patients is unclear as discussed by the authors, however, there is no evidence that omega-3 fatty acids derived from fish oil reduce cardiovascular disease.
Journal ArticleDOI
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Leo A. B. Joosten,Mihai G. Netea,Giamila Fantuzzi,Marije I. Koenders,Monique M. Helsen,Helmut Sparrer,Christine T.N. Pham,Jos W. M. van der Meer,Charles A. Dinarello,Wim B. van den Berg +9 more
TL;DR: It is suggested that inhibitors of caspase 1 are not able to interfere with the whole spectrum of IL-1beta production, and therefore such inhibitors may be of therapeutic value only in inflammatory conditions in which limited numbers of neutrophils are present.
Journal ArticleDOI
Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover.
Jason Faller,Irving H. Fox +1 more
TL;DR: The data indicate that ethanol increases urate synthesis by enhancing the turnover of adenine nucleotides in patients with gout through increased production and decreased excretion of uric acid.
Journal ArticleDOI
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase.
Yasuhiro Takano,Kumiko Hase-Aoki,Hideki Horiuchi,Lin Zhao,Yoshinori Kasahara,Shiro Kondo,Michael Becker +6 more
TL;DR: Results demonstrate that febuxostat is a potent non-purine, selective inhibitor of XO, and could be useful for the treatment of hyperuricemia and gout.