Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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The inflammatory process in acute gouty arthritis. i. activation of hageman factor by sodium urate crystals.
TL;DR: It is proposed that monosodium urate and calcium pyrophosphate crystals initiate acute arthritis by activating Hageman factor in synovial fluid which causes increased capillary permeability and an accumulation of leukocytes, which is perpetuated by additional inflammatory mediators produced by the accumulation ofLeukocytes.
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Evaluation of renal handling of uric acid in essential hypertension: hyperuricemia related to decreased urate secretion.
TL;DR: Urate secretion was significantly reduced in hypertensive patients and in those with hyperuricemia showed a twofold decrease, indicating that impaired tubular secretion of urate is a potential mechanism of hyperuricaemia in essential hypertension.
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Flavonoid modulation of human neutrophil function
William W. Busse,William W. Busse,Douglas E. Kopp,Douglas E. Kopp,Middleton Elliott,Middleton Elliott +5 more
TL;DR: It is demonstrated that certain flavonoids are not uniformly active in inhibiting neutrophil CL, beta-glucuronidase release, or superoxide generation.
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History of the use of colchicum and related medicaments in gout; with suggestions for further research.
TL;DR: At the present time colchicine and its derivatives, as well as other mitotic-arresting drugs, are of considerable importance in the field of cancer research, and it is this latter role that concerns us most here.
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Uricosuric action of cholecystographic agents. A possible factor in nephrotoxicity.
TL;DR: The oral cholecystographic agents are highly lipid-soluble carboxylic acids and resemble probenecid and some other uricosuric agents in this respect.