Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
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Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Anakinra's efficacy is variable in refractory gout: report of ten cases.
TL;DR: Although a short course of anakinra resulted in favorable outcomes for some of the authors' patients, response rates were poorer in this study than in previously published reports, and relapses were common.
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Validation of a radiographic damage index in chronic gout.
TL;DR: A modified Sharp/van der Heijde system accurately and reliably represents radiographic joint damage in chronic gout and was able to discriminate between early and advanced disease.
Journal Article
Cardiovascular risk factors and HDL-cholesterol levels in obesity.
TL;DR: Obese patients must be considered at high risk with respect to the development of cardiovascular disease, as a stronger influence of age than body weight on blood pressure, serum levels of total cholesterol, LDL-cholesterol, triglycerides and blood glucose levels is revealed.
Journal Article
Allopurinol hypersensitivity syndrome: a preventable severe cutaneous adverse reaction?
TL;DR: Allopurinol hypersensitivity syndrome is a life-threatening cutaneous adverse reaction that should be initiated under clear indications with appropriate dosages, and potential associations with this syndrome include the Chinese race, the elderly, and patients with underlying renal impairment.
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Hypouricemia due to isolated renal tubular defect: Dalmatian dog mutation in man
TL;DR: It is suggested that this man found to have low serum urate concentrations during evaluation for recurrent urinary calcium oxalate stones had a genetically determined renal abnormality affecting tubular re absorption of uric acid; a similar defect is present in the Dalmatian coachhound.